Oligodendrocytes go with the flow: Meningeal lymphatics promote myelin integrity

Eric D Garcia; Jonah R Chan

doi:10.1016/j.immuni.2024.09.006

Oligodendrocytes go with the flow: Meningeal lymphatics promote myelin integrity

Immunity. 2024 Oct 8;57(10):2255-2257. doi: 10.1016/j.immuni.2024.09.006.

Authors

Eric D Garcia¹, Jonah R Chan²

Affiliations

¹ Department of Neurology, Weill Institute for Neurosciences, University of California San Francisco, San Francisco, CA, USA; Neuroscience Graduate Program, University of California San Francisco, San Francisco, CA, USA. Electronic address: [email protected].
² Department of Neurology, Weill Institute for Neurosciences, University of California San Francisco, San Francisco, CA, USA; Neuroscience Graduate Program, University of California San Francisco, San Francisco, CA, USA. Electronic address: [email protected].

PMID: 39383839
DOI: 10.1016/j.immuni.2024.09.006

Abstract

The meningeal lymphatics system plays diverse roles in facilitating neuroimmune function at brain borders, yet its specific contribution toward glial function and homeostasis is not known. In this issue of Immunity, Das Neves et al. (2024) describe a novel role for the meningeal lymphatics in maintaining oligodendrocyte survival and myelination.

MeSH terms

Animals
Homeostasis
Humans
Lymphatic Vessels / immunology
Lymphatic Vessels / physiology
Meninges* / immunology
Myelin Sheath* / metabolism
Oligodendroglia* / metabolism
Oligodendroglia* / physiology