Abstract
Tumors evade immune detection by downregulating antigen presentation and hindering immune responses. Type 1 conventional dendritic cells (cDC1s) are vital in stimulating cytotoxic T cells against tumors. Ascic et al. are now demonstrating the in situ ability of PU.1, IRF8, and BATF3 (PIB) transcription factors to directly reprogram a plethora of tumors bypassing the suppressive effects of the tumor microenvironment, and leading to overall tumor regression while eliciting a systemic immune response that can protect from secondary tumor induction.
Keywords:
PIB; cDC1; immunotherapy; in situ reprogramming.
MeSH terms
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Animals
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Basic-Leucine Zipper Transcription Factors / genetics
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Basic-Leucine Zipper Transcription Factors / immunology
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Basic-Leucine Zipper Transcription Factors / metabolism
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Cellular Reprogramming*
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Dendritic Cells / immunology
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Humans
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Immunotherapy* / methods
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Interferon Regulatory Factors / genetics
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Interferon Regulatory Factors / metabolism
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Neoplasms* / immunology
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Neoplasms* / therapy
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Proto-Oncogene Proteins / genetics
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Trans-Activators / genetics
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Tumor Microenvironment
Substances
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Basic-Leucine Zipper Transcription Factors
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BATF3 protein, human
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interferon regulatory factor-8
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Interferon Regulatory Factors
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proto-oncogene protein Spi-1
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Proto-Oncogene Proteins
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Trans-Activators