Asian Neonatal Network Collaboration (AsianNeo): a study protocol for international collaborative comparisons of health services and outcomes to improve quality of care for sick newborn infants in Asia - survey, cohort and quality improvement studies

Tetsuya Isayama; Fuyu Miyake; Rinawati Rohsiswatmo; Rizalya Dewi; Yuri Ozawa; Seiichi Tomotaki; Naho Morisaki; Seok Chiong Chee; Siew Hong Neoh; Ma Lourdes S Imperial; Belen Amparo E Velasco; Yun Sil Chang; Su Jin Cho; YoungAh Youn; Bin Huey Quek; Woei Bing Poon; Zubair Amin; Kapila Jayaratne; Saman Kumara; Yuh-Jyh Lin; Jui-Hsing Chang; Hsiang Yu Lin; Ming-Chih Lin; Pracha Nuntnarumit; Sopapan Ngerncham; Chatchay Prempunpong; Pathaporn Prempraphan; Sarayut Supapannachart; Satoshi Kusuda; Asian Neonatal Network Collaboration (AsianNeo)

doi:10.1136/bmjopen-2023-082712

Asian Neonatal Network Collaboration (AsianNeo): a study protocol for international collaborative comparisons of health services and outcomes to improve quality of care for sick newborn infants in Asia - survey, cohort and quality improvement studies

BMJ Open. 2024 Jul 13;14(7):e082712. doi: 10.1136/bmjopen-2023-082712.

Authors

Tetsuya Isayama^{1

2}, Fuyu Miyake³, Rinawati Rohsiswatmo^{4

5}, Rizalya Dewi⁶, Yuri Ozawa⁷, Seiichi Tomotaki⁸, Naho Morisaki⁹, Seok Chiong Chee¹⁰, Siew Hong Neoh¹⁰, Ma Lourdes S Imperial¹¹, Belen Amparo E Velasco¹², Yun Sil Chang¹³, Su Jin Cho¹⁴, YoungAh Youn¹⁵, Bin Huey Quek¹⁶, Woei Bing Poon¹⁷, Zubair Amin¹⁸, Kapila Jayaratne¹⁹, Saman Kumara²⁰, Yuh-Jyh Lin²¹, Jui-Hsing Chang²², Hsiang Yu Lin²³, Ming-Chih Lin²⁴, Pracha Nuntnarumit²⁵, Sopapan Ngerncham²⁶, Chatchay Prempunpong²⁷, Pathaporn Prempraphan²⁸, Sarayut Supapannachart²⁷, Satoshi Kusuda²; Asian Neonatal Network Collaboration (AsianNeo)

Collaborators

Asian Neonatal Network Collaboration (AsianNeo):
Isra Firmansyah, Pertin Sianturi, Eny Yantri, Afifa Ramadanti, Henri Azis, Ied Imelda, Rizalya Dewi, Mustarim Mustarim, Benny Sana Putra, Leni Ervina Jumnalis, Andhika Tiurmaida Hutapea, Rinawati Rohsiswatmo, Nadia Dwi Insani, Agnes Yunie Purwita Sari, Ellen Sianipar, Naomi Esthernita Dewanto, Thomas Harry Adoe, Arif Budiman, Arief Budiman, Tetty Yuniarti, Adhie Nur Radityo S, Dwi Hidayah, Tunjung Wibowo, Kartika Darma Handayani, Risa Etika, Dina Djojo Husodo, Brigitta Ida Resita Vebrianti Corebima, Retno Wulandari, Made Sukmawati, I Ketut Adi Wirawan, Pudji Andayani, Made Yuliari, Rocky Wilar, Ema Alasiry, James Thimoty, Sandra Bulan, Takashi Nasu, Yukiteru Tachibana, Ayumu Noro, Toshihiko Mori, Ken Nagaya, Masaru Shirai, Toru Ishioka, Toshiya Saito, Yosuke Kaneshi, Masaki Kobayashi, Nobuko Shiono, Nobuhiro Takahashi, Yusuke Ohkado, Tatsuro Satomi, Mika Nakajima, Eiki Nakamura, Tomofumi Ikeda, Genichiro Sotodate, Mari Ishii, Toru Huchimukai, Takahide Hosokawa, Rikio Suzuki, Masatoshi Sanjo, Michiya Kudo, Takushi Hanita, Hirokazu Arai, Masato Ito, Satoshi Niwa, Masanari Kawamura, Satoshi Watanabe, Yousuke Sudo, Hiroshi Yoshida, Tsutomu Ishii, Takashi Imamura, Maki Sato, Yoshiya Yukitake, Yayoi Miyazono, Goro Asada, Yumi Kono, Yasuaki Kobayashi, Hiroshi Suzuki, Yasushi Oki, Kenji Ichinomiya, Toru Fujiu, Hideaki Fukushima, Tetsuya Kunikata, Fumihiko Namba, Masaki Shimizu, Shigeharu Hosono, Chika Morioka, Motoichiro Sakurai, Hiroshi Matsumoto, Naoto Nishizaki, Satoshi Toishi, Harumi Otsuka, Masahiko Sato, Kenichiro Hirakawa, Kenichiro Hosoi, Keiji Goishi, Yuji Ito, Kyone Ko, Hiromichi Shoji, Atsuo Miyazawa, Yuko Nagaoki, Naoki Ito, Ken Masunaga, Reiko Kushima, Sakae Kumasaka, Manabu Sugie, Daisuke Haruhara, Masahiro Kobayashi, Satsuki Kakiuchi, Riki Nishimura, Kaoru Okazaki, Hitoshi Yoda, Atsushi Nakao, Ichiro Morioka, Daisuke Ogata, Fumihiko Ishida, Daisuke Nishi, Miho Sato, Ayako Fukuyama, Kuriko Nakamura, Kanji Ogo, Masahiko Murase, Katsuaki Toyoshima, Isamu Hokuto, Maha Suzuki, Atsushi Uchiyama, Yoshio Shima, Hidehiko Nakanishi, Atsushi Nemoto, Akira Shimazaki, Tatsuya Yoda, Yukihide Miyosawa, Takehiko Hiroma, Yosuke Shima, Gen Kuratsuji, Yoshihisa Nagayama, Tohei Usuda, Rei Kobayashi, Hiroaki Imamura, Takeshi Hutani, Taketoshi Yoshida, Azusa Kobayashi, Kazuhide Ohta, Shuya Nagaoki, Yasuhisa Ueno, Toru Ando, Ritsuyo Taguchi, Takashi Okuno, Hiroshi Yamamoto, Takeshi Arakawa, Shinji Usui, Yasushi Uchida, Takashi Tachibana, Tokuso Murabayashi, Tadayuki Kumagai, Shigeru Oki, Reiji Nakano, Taizo Ueno, Mitsuhiro Ito, Masami Shirai, Akira Oishi, Hikaru Yamamoto, Hiroshi Takeshita, Yuichi Kato, Masashi Hayashi, Kuniko Ieda, Koji Takemoto, Toshiyuki Ono, Masashi Miyata, Makoto Ohshiro, Masanori Kowaki, Osamu Shinohara, Yasunori Koyama, Osuke Iwata, Takahiro Muramatsu, Akinobu Taniguchi, Naoki Kamata, Hiroshi Uchizono, Kanemasa Maki, Takahide Yanagi, Kenji Nakamura, Masahito Yamamoto, Jitsuko Ohira, Machiko Sawada, Kozue Shiomi, Ryosuke Araki, Daisuke Kinoshita, Ryuji Hasegawa, Akira Nishimura, Hiroshi Komatsu, Koji Nozaki, Shinsuke Adachi, Toru Yamakawa, Masahiko Kai, Hiroshi Sumida, Hirotaka Minami, Kenji Mine, Reiko Negi, Satoru Ogawa, Ryoko Yoshinare, Yasuyuki Tokunaga, Kiyoaki Sumi, Akihiro Takatera, Atsushi Ogihara, Satoshi Onishi, Taho Kim, Hiroyuki Ichiba, Misao Yoshii, Hitomi Okabe, Yoshio Kusumoto, Shinya Hirano, Hiroshi Mizumoto, Yae Michinomae, Makoto Nabetani, Takeshi Morisawa, Masaaki Ueda, Takahiro Okutani, Masaru Yamakawa, Kazumichi Fujioka, Tomoaki Ioroi, Takeshi Utsunomiya, Seiji Yoshimoto, Tamaki Ohashi, Toshiya Nishikubo, Ken Kumagaya, Akiko Tamura, Masumi Miura, Yuki Hasegawa, Rie Kanai, Kei Takemoto, Koichi Tsukamoto, Misao Kageyama, Takashi Nakano, Hironobu Tokumasu, Moriharu Sugimoto, Rie Fukuhara, Yutaka Nishimura, Seiichi Hayakawa, Yasuhiko Sera, Masahiro Tahara, Shinosuke Fukunaga, Keiko Hasegawa, Kazumasa Takahashi, Hiroshi Tateishi, Tomomasa Terada, Takashi Yamagami, Takahiko Saijo, Kosuke Koyano, Toru Kuboi, Osamu Matsuda, Shinosuke Akiyoshi, Takahiro Motoki, Yoichi Kondo, Yusei Nakata, Hideaki Harada, Masayuki Ochiai, Toshinori Nakashima, Toshiharu Hikino, Shutaro Suga, Mitsuaki Unno, Hiroshi Kanda, Yasushi Takahata, Hiroyasu Kawano, Takayuki Kokubo, Toshimitsu Takayanagi, Mikio Aoki, Muneichiro Sumi, Fumiko Kinoshita, Tsutomu Ogata, Kei Inomata, Masanori Iwai, Naoki Fukushima, Koichi Iida, Mitsushi Goshi, Yuki Kodama, Shuichi Yanagibe, Yuko Maruyama, Takuya Tokuhisa, Yoriko Kisato, Tatsuo Oshiro, Kazuhiko Nakasone, Asao Yara, Yun Sil Chang, Ee-Kyung Kim, ChangWon Choi, Young-Ah Youn, Jae Won Shim, Juyoung Lee, Jang Hoon Lee, Soon Min Lee, Ga Won Jeon, Byong Sop Lee, Jin A Lee, Jae Woo Lim, Su Jin Cho, Zuraidah Abdul Latif, Zainah Shaikh Hedra, Baizura Jamaluddin, Hasri Hafidz, Zainab Ishak, Geok Hoon Ngian, Chiong Hung Kiew, Mehala Devi Baskaran, Maslina Mohamad, Chee Sing Wong, Rozitah Razman, Maneet Kaur, Ann Cheng Wong, Choo Hau Lim, Maizatul Akmar, Sheila Gopal Krishnan, Chae Hee Chieng, Chong Meng Choo, Eric Boon-Kuang Ang, AngShiau Chuen Diong, Angeline Seng-Lian Wan, Sharifah Huda Engku Alwi, Kwee Ching See, Rohani Abdul Jalil, Agnes Suganthi, Mei Ling Lee, Ee Lee Ang, Pauline Poh-Ling Choo, Lee Ser Chia, Azanna Ahmad Kamar, Anand Mohan A/L Mohana Lal, Zainab Ishak, Agnes Huei-Hwen Foo, Abdul Nasir Mohamed Abdul Kadher, Ma Lourdes Imperial, Belen Velasco, Ma Esterlita V Uy, Daisy Evangeline Garcia, Eleanor Dr Cuarte, Jacinto Blas Mantaring, Bin Huey Quek, Woei Bing Poon, Zubair Amin, Saman Kumara, Kapila Jayaratne, Nethmini Thenuwara, Ming-Chou Chiang, Lan-Wan Wang, Chih-Cheng Chen, Xiao-Ping Wang, Hsiu-Ling Chen, Yi-Li Hung, Yung Chieh Lin, Pen-Hua Su, Yung-Ning Yang, Po-Nein Tsao, Shu-Chi Mu, Hung-Chih Lin, Ming-Chih Lin, Mei-Jy Jeng, Hung-Yang Chang, Liang-Ti Huang, Yi-Yu Su, Shau-Ru Ho, Yan-Yan Ng, Kai-Ti Tseng, Yi-Yin Chen, Tsung-Yu Wu, Wei-Tse Chiu, Li-Jung Fang, Kao-Hsian Hsieh, Anavat Bupphachareonsuk, Anchalee Limrungsikul, Anita Luvira, Anucha Thatrimontrichai, Buranee Swatesutipun, Buranee Yangthara, Chayatat Ruangkit, Cholticha Laohajeeraphan, Hathitip Chaiprapa, Junya Jirapradittha, Kanmalee Jenjarat, Kannikar Booranavanich, Namtip Intub, Narongsak Nakwan, Patcharin Thanomsingh, Pirarat Kotcharit, Piyawan Phummaphuti, Pornpimon Janyoungsak, Prapaiporn Chongkongkiat, Rapeephun Hansuebsai, Roongrawee Torbunsupachai, Santi Punnahitanan, Shanika Kosarat, Sommon Jindakul, Sopida Tanthawat, Sudarat Sirichaipornsak, Sudatip Kositamongkol, Supamas Supabanpot, Suparat Tipprasert, Tanin Pirunnet, Thanatda Siriporn, Usakorn Taesiri, Vasita Jirasakuldech

Affiliations

¹ Division of Neonatology, National Center for Child Health and Development, Setagaya-ku, Japan [email protected].
² Neonatal Research Network of Japan, Tokyo, Japan.
³ National Center for Child Health and Development, Setagaya-ku, Japan.
⁴ Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia.
⁵ Dr. Cipto Mangunkusumo Hospital, Jakarta, Indonesia.
⁶ Budhi Mulia Mother and Child Hospital, Pekanbaru, Indonesia.
⁷ Kyorin University, Mitaka, Japan.
⁸ Department of Pediatrics, Kyoto University, Kyoto, Japan.
⁹ Department of Social Medicine, National Center for Child Health and Development, Setagaya-ku, Japan.
¹⁰ Faculty of Health and Medical Sciences, Taylor's University, Subang Jaya, Selangor, Malaysia.
¹¹ Dr. Jose Fabella Memorial Hospital, Manila, Philippines.
¹² Philippine Children's Medical Center, Manila, Philippines.
¹³ Department of Pediatrics, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea (Republic of).
¹⁴ Pediatrics, Ewha Womans University College of Medicine, Seoul, Korea (Republic of).
¹⁵ Department of Pediatrics, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea (Republic of).
¹⁶ Department of Neonatology, KK Women's and Children's Hospital, Singapore.
¹⁷ Department of Neonatology and Developmental Medicine, Singapore General Hospital, Singapore.
¹⁸ Department of Neonatology, Khoo Teck Puat-National University Children's Medical Institute, National University Hospital, Singapore.
¹⁹ Maternal & Child Morbidity & Mortality Surveillance Unit, Family Health Bureau, Colombo, Sri Lanka.
²⁰ Castle Street Hospital for Women, Colombo, Western Province, Sri Lanka.
²¹ National Cheng Kung University Hospital, Tainan, Taiwan.
²² Taipei MacKay Memorial Hospital, Taipei, Taiwan.
²³ China Medical University Children's Hospital, Taichung, Taiwan.
²⁴ Pediatrics, Taichung Veterans General Hospital, Taichung, Taiwan.
²⁵ Pediatrics, Mahidol University Faculty of Medicine Ramathibodi Hospital, Bangkok, Thailand.
²⁶ Mahidol University, Bangkok, Thailand.
²⁷ Mahidol University Faculty of Medicine Ramathibodi Hospital, Bangkok, Thailand.
²⁸ Navamindradhiraj University, Bangkok, Thailand.

Abstract

Introduction: Reducing neonatal deaths in premature infants in low- and middle-income countries is key to reducing global neonatal mortality. International neonatal networks, along with patient registries of premature infants, have contributed to improving the quality of neonatal care; however, the involvement of low-to-middle-income countries was limited. This project aims to form an international collaboration among neonatal networks in Asia (AsianNeo), including low-, middle- and high-income countries (or regions). Specifically, it aims to determine outcomes in sick newborn infants, especially very low birth weight (VLBW) infants or very preterm infants, with a view to improving the quality of care for such infants.

Methods and analysis: Currently, AsianNeo comprises nine neonatal networks from Indonesia, Japan, Malaysia, Philippines, Singapore, South Korea, Sri Lanka, Taiwan and Thailand. AsianNeo will undertake the following four studies: (1) institutional questionnaire surveys investigating neonatal intensive care unit resources and the clinical management of sick newborn infants, with a focus on VLBW infants (nine countries/regions); (2) a retrospective cohort study to describe and compare the outcomes of VLBW infants among Asian countries and regions (four countries/regions); (3) a prospective cohort study to develop the AsianNeo registry of VLBW infants (six countries/regions); and (4) implementation and evaluation of educational and quality improvement projects in AsianNeo countries and regions (nine countries/regions).

Ethics and dissemination: The study protocol was approved by the Research Ethics Board of the National Center for Child Health and Development, Tokyo, Japan (reference number 2020-244, 2022-156). The study findings will be disseminated through educational programmes, quality improvement activities, conference presentations and medical journal publications.

Keywords: International health services; Mortality; NEONATOLOGY; Neonatal intensive & critical care.

MeSH terms

Asia
Humans
Infant
Infant Mortality
Infant, Newborn
Infant, Premature
Infant, Very Low Birth Weight
Intensive Care Units, Neonatal / organization & administration
Intensive Care Units, Neonatal / standards
International Cooperation
Quality Improvement* / organization & administration
Quality of Health Care
Research Design
Retrospective Studies
Surveys and Questionnaires