Dimensions of experienced gender and prospective self-injurious thoughts and behaviors in preadolescent children: A national study

J Affect Disord. 2025 Jan 15:369:467-474. doi: 10.1016/j.jad.2024.10.033. Epub 2024 Oct 9.

Abstract

Objectives: Gender diverse youth face higher risk of engaging in self-injurious thoughts and behaviors (SITBs) compared to cisgender youth. Limitations in past research include a focus on older adolescents, an emphasis on specific gender identity labels that may not be inclusive of the range of youth gender experiences, and reliance on cross-sectional data. Thus, the current study prospectively evaluated dimensions of experienced gender in relation to first-onset SITBs among preadolescents.

Methods: Data were drawn from the Adolescent Brain Cognitive Development Study, a longitudinal study of youth across the United States. Youth (n = 7909) were aged 10-11 during initial assessment, and follow-up was conducted one year later. Two dimensions of experienced gender, felt-gender incongruence (not feeling aligned with the gender associated with one's sex assigned at birth) and gender non-contentedness (feeling dissatisfaction with the gender associated with one's sex assigned at birth), were assessed. Primary outcomes included non-suicidal self-injury (NSSI), suicidal ideation (SI), and suicide attempts (SA).

Results: Logistic regressions were conducted stratified by sex assigned at birth. For youth assigned female at birth, felt-gender incongruence was prospectively associated with first-onset NSSI and SI and gender non-contentedness was prospectively associated with first-onset of NSSI. For youth assigned male at birth, gender non-contentedness was prospectively associated with first-onset SI. Diverse experienced gender did not prospectively predict SA.

Conclusions: Dimensions of experienced gender may be associated with subsequent first-onset SITBs among preadolescents. These findings support the need for future research on risk and protective factors that may mediate or moderate this relationship.

Keywords: Gender diversity; Preadolescence; Self-injury; Suicide.

MeSH terms

  • Child
  • Female
  • Gender Identity
  • Humans
  • Longitudinal Studies
  • Male
  • Prospective Studies
  • Self-Injurious Behavior* / epidemiology
  • Self-Injurious Behavior* / psychology
  • Sex Factors
  • Suicidal Ideation*
  • Suicide, Attempted* / psychology
  • Suicide, Attempted* / statistics & numerical data
  • United States / epidemiology