N-Heterocyclic Carbene Catalysis for Polycyclic Benzazepines Assembly: Regioselective Intramolecular Tandem Radical Cyclization

Org Lett. 2024 Oct 25;26(42):9068-9072. doi: 10.1021/acs.orglett.4c03303. Epub 2024 Oct 11.

Abstract

A variety of polycyclic benzazepines were rapidly constructed by NHC-catalyzed regioselective redox-neutral intramolecular tandem cyclization. Initial mechanistic studies revealed that a SET radical process was possibly involved.