JTH in Clinic: management of low-risk pulmonary embolism

J Thromb Haemost. 2024 Dec;22(12):3406-3414. doi: 10.1016/j.jtha.2024.09.019. Epub 2024 Oct 10.

Abstract

Pulmonary embolism (PE) is a common cardiovascular disease diagnosis in emergency departments that can be associated with significant morbidity and mortality. One of the first steps after diagnosing PE is to risk stratify for adverse outcomes using risk scores such as PE Severity Index and European Society of Cardiology risk scheme. While intermediate- and high-risk PE patients should be admitted to the hospital, there is increasing evidence to support early discharge and home-based anticoagulation therapy for low-risk patients. The Hestia criteria encompass many of the clinicians' considerations for who may be suitable for early discharge, considering both medical and social factors. Additionally, professional guidelines have provided algorithms on determining which low-risk patients may be suitable. Despite this, low-risk acute PE patients are still often admitted for inpatient treatment. In this review, we present a case-based approach on how to risk stratify and evaluate patients who may be good candidates for early discharge and home therapy.

Keywords: anticoagulation therapy; emergency medicine; pulmonary embolism; risk assessment; venous thromboembolism.

Publication types

  • Review
  • Case Reports

MeSH terms

  • Aged
  • Algorithms
  • Anticoagulants* / therapeutic use
  • Clinical Decision-Making
  • Female
  • Home Care Services
  • Humans
  • Male
  • Middle Aged
  • Patient Discharge*
  • Patient Selection
  • Pulmonary Embolism* / diagnosis
  • Pulmonary Embolism* / therapy
  • Risk Assessment
  • Risk Factors
  • Treatment Outcome

Substances

  • Anticoagulants