Apocarotenoids from the fresh roots of Rehmannia glutinosa and their anti-pulmonary fibrosis activity

Xiang-Da Li; Yan-Gang Cao; Yu-Han Zhang; Ying-Jie Ren; Meng-Nan Zeng; Yan-Ling Liu; Xu Chen; Xin-Yi Ma; Bing-Xian Zhao; Xiao-Ke Zheng; Wei-Sheng Feng

doi:10.1016/j.fitote.2024.106247

Apocarotenoids from the fresh roots of Rehmannia glutinosa and their anti-pulmonary fibrosis activity

Fitoterapia. 2024 Oct 10:179:106247. doi: 10.1016/j.fitote.2024.106247. Online ahead of print.

Authors

Affiliations

¹ School of Pharmacy, Henan University of Chinese Medicine, Zhengzhou 450046, China; The Engineering and Technology Center for Chinese Medicine Development of Henan Province, Zhengzhou 450046, China.
² School of Pharmacy, Henan University of Chinese Medicine, Zhengzhou 450046, China; The Engineering and Technology Center for Chinese Medicine Development of Henan Province, Zhengzhou 450046, China; Collaborative Innovation Center for Chinese Medicine and Respiratory Diseases Co-Construction by Henan province & Education Ministry of P. R. China, Zhengzhou 450046, China. Electronic address: [email protected].
³ School of Pharmacy, Henan University of Chinese Medicine, Zhengzhou 450046, China; The Engineering and Technology Center for Chinese Medicine Development of Henan Province, Zhengzhou 450046, China; Collaborative Innovation Center for Chinese Medicine and Respiratory Diseases Co-Construction by Henan province & Education Ministry of P. R. China, Zhengzhou 450046, China. Electronic address: [email protected].

PMID: 39395698
DOI: 10.1016/j.fitote.2024.106247

Abstract

Six undescribed compounds (1-6) and twenty-three known analogues (7-29) were isolated from the fresh roots of Rehmannia glutinosa. The structures of the compounds (1-29) were established through the application of spectroscopic analysis. Compounds 3, 4, 6, 8, 13, 18, 21, 22, 25, and 28 exhibited excellent anti-pulmonary fibrosis activity. The potential mechanistic pathway of 3 was also investigated, whose results indicate that compound 3 ameliorate TGF-β1 induced BEAS-2B cell injury via PI3K/AKT/NF-κB signaling pathway.

Keywords: Anti-pulmonary fibrosis; Apocarotenoids; Rehmannia glutinosa; Scrophulariaceae.