Apocarotenoids from the fresh roots of Rehmannia glutinosa and their anti-pulmonary fibrosis activity

Fitoterapia. 2024 Dec:179:106247. doi: 10.1016/j.fitote.2024.106247. Epub 2024 Oct 10.

Abstract

Six undescribed compounds (1-6) and twenty-three known analogues (7-29) were isolated from the fresh roots of Rehmannia glutinosa. The structures of the compounds (1-29) were established through the application of spectroscopic analysis. Compounds 3, 4, 6, 8, 13, 18, 21, 22, 25, and 28 exhibited excellent anti-pulmonary fibrosis activity. The potential mechanistic pathway of 3 was also investigated, whose results indicate that compound 3 ameliorate TGF-β1 induced BEAS-2B cell injury via PI3K/AKT/NF-κB signaling pathway.

Keywords: Anti-pulmonary fibrosis; Apocarotenoids; Rehmannia glutinosa; Scrophulariaceae.

MeSH terms

  • Animals
  • Cell Line
  • China
  • Humans
  • Molecular Structure
  • NF-kappa B* / metabolism
  • Phosphatidylinositol 3-Kinases / metabolism
  • Phytochemicals* / isolation & purification
  • Phytochemicals* / pharmacology
  • Plant Roots* / chemistry
  • Proto-Oncogene Proteins c-akt / metabolism
  • Pulmonary Fibrosis* / drug therapy
  • Rehmannia* / chemistry
  • Signal Transduction / drug effects
  • Transforming Growth Factor beta1 / metabolism

Substances

  • NF-kappa B
  • Phytochemicals
  • Transforming Growth Factor beta1
  • Proto-Oncogene Proteins c-akt
  • Phosphatidylinositol 3-Kinases