Lignans and phenols with potential anti-inflammatory effect from the stems of Mallotus paxii Pamp

Yan Huang; Ping Hou; Liwei Pan; Jian Li; Xiaoqin Liang; Chenyang Ren; Liuting Peng; Chunqiu Gan; Weifeng Xu; Ruiyun Yang; Jun Li; Xinlan Guan

doi:10.1016/j.fitote.2024.106253

Lignans and phenols with potential anti-inflammatory effect from the stems of Mallotus paxii Pamp

Fitoterapia. 2024 Oct 11:179:106253. doi: 10.1016/j.fitote.2024.106253. Online ahead of print.

Authors

Yan Huang¹, Ping Hou², Liwei Pan², Jian Li³, Xiaoqin Liang², Chenyang Ren², Liuting Peng², Chunqiu Gan², Weifeng Xu², Ruiyun Yang², Jun Li⁴, Xinlan Guan⁵

Affiliations

¹ State Key Laboratory for Chemistry and Molecular Engineering of Medicinal Resources, Key Laboratory for Chemistry and Molecular Engineering of Medicinal Resources (Ministry of Education of China), Collaborative Innovation Center for Guangxi Ethnic Medicine, School of Chemistry and Pharmaceutical Sciences, Guangxi Normal University, Guilin 541004, China; Guangxi Key Laboratory of Tradtitional Chinese Medicine Quality Standards, Guangxi Institute of Chinese Medicine & Pharmaceutical Science, Nanning 530022, China.
² State Key Laboratory for Chemistry and Molecular Engineering of Medicinal Resources, Key Laboratory for Chemistry and Molecular Engineering of Medicinal Resources (Ministry of Education of China), Collaborative Innovation Center for Guangxi Ethnic Medicine, School of Chemistry and Pharmaceutical Sciences, Guangxi Normal University, Guilin 541004, China.
³ Peoples' Hospital of Pubei, Pubei 535300, China.
⁴ State Key Laboratory for Chemistry and Molecular Engineering of Medicinal Resources, Key Laboratory for Chemistry and Molecular Engineering of Medicinal Resources (Ministry of Education of China), Collaborative Innovation Center for Guangxi Ethnic Medicine, School of Chemistry and Pharmaceutical Sciences, Guangxi Normal University, Guilin 541004, China. Electronic address: [email protected].
⁵ Peoples' Hospital of Pubei, Pubei 535300, China. Electronic address: [email protected].

PMID: 39396653
DOI: 10.1016/j.fitote.2024.106253

Abstract

Phytochemical investigation of the stems of Mallotus paxii Pamp. led to the isolation and identification of four new compounds, including three neolignans (1-3) and one phenol (13), along with eight known neolignans (4-12) and one known phenol (14). Their structures were determined by spectroscopic methods, including NMR, MS and ECD analyses. Bioassay demonstrated that malloapelin A (4) exhibited a most potent anti-inflammatory activity to NO release with IC₅₀ value of 21.32 μM. Furthermore, malloapelin A (4) markedly decreased the secretion of TNF-α, iNOS, and NF-κB and inhibited the expression of COX-2 and NF-κB/p65 in LPS-induced RAW264.7 cells in a dose-dependent manner.

Keywords: Anti-inflammatory effect; Mallotenuifo A; Mallotenuifo D; Mallotus Lour.; Mallotus paxii Pamp..