Myocardial extracellular volume measurement using cardiac computed tomography

Rahul G Muthalaly; Timothy Abrahams; Andrew Lin; Kush Patel; Sean Tan; Damini Dey; Donghee Han; Balaji K Tamarappoo; Stephen J Nicholls; Nitesh Nerlekar

doi:10.1007/s10554-024-03226-4

Myocardial extracellular volume measurement using cardiac computed tomography

Int J Cardiovasc Imaging. 2024 Oct 14. doi: 10.1007/s10554-024-03226-4. Online ahead of print.

Authors

Rahul G Muthalaly^{1

2}, Timothy Abrahams^{1

2}, Andrew Lin^{1

2

3}, Kush Patel³, Sean Tan^{1

2}, Damini Dey⁴, Donghee Han⁴, Balaji K Tamarappoo⁵, Stephen J Nicholls^{1

2}, Nitesh Nerlekar^{6

7

8}

Affiliations

¹ Victorian Heart Institute, Monash University, 631 Blackburn Road, Clayton, VIC, 3168, Australia.
² Victorian Heart Hospital, Monash Health, Clayton, VIC, Australia.
³ St. Bartholomew's Heart Centre, London, UK.
⁴ Department of Biomedical Sciences, Biomedical Imaging Research Institute, Cedars-Sinai Medical Centre, Los Angeles, CA, USA.
⁵ Cardiovascular Institute, Indiana University School of Medicine, Indianapolis, IN, USA.
⁶ Victorian Heart Institute, Monash University, 631 Blackburn Road, Clayton, VIC, 3168, Australia. [email protected].
⁷ Victorian Heart Hospital, Monash Health, Clayton, VIC, Australia. [email protected].
⁸ Baker Heart and Diabetes Institute, Commercial Road, Melbourne, 3004, Australia. [email protected].

PMID: 39400790
DOI: 10.1007/s10554-024-03226-4

Abstract

Myocardial fibrosis is a common endpoint of many cardiac diseases and increasingly recognized as a predictor of heart failure, arrhythmia, and death. Recent studies have utilised cardiac computed tomography (CT) scans with delayed phase imaging to quantify diffuse fibrosis of the myocardium. CT extracellular volume (CT-ECV) measurement correlates well with CMR and histological myocardial fibrosis. Furthermore, CT-ECV predicts outcomes such as death, heart failure and arrhythmia in various disease states. This review summarizes the rationale and methodology behind CT-ECV measurement and provides a detailed summary of the current clinical evidence for the use of CT-ECV.

Keywords: Cardiomyopathies; Fibrosis; Multidetector Computed Tomography; Myocardium.

Publication types

Review