Management of inflammaging in kidney diseases: focusing on the current investigational drugs

Expert Opin Investig Drugs. 2024 Nov;33(11):1153-1166. doi: 10.1080/13543784.2024.2417755. Epub 2024 Oct 16.

Abstract

Introduction: To improve kidney disease treatments, it is crucial to understand how inflammaging affects patients´ longevity. We could potentially slow down kidney disease progression and enhance longevity by targeting specific pathways involved in inflammaging with potential drugs.

Areas of covered: This review offers an updated overview of 'anti-inflammaging' drugs currently in the kidney disease research pipeline, as well as those with potential for future therapeutic use. Furthermore, these drugs are categorized according to their mechanisms, including targeting inflammation, immune and metabolic regulation, oxidative stress, senescence, and autophagy, as demonstrated in preclinical and early clinical trials. Additionally, the review provides insights into key challenges and opinions for future advancements in this field.

Expert opinion: We reviewed recent advancements in applying different therapies to mitigate inflammaging in kidney diseases. We underscore the need for continued research to elucidate the complex pathways underlying inflammaging, which will be essential for the development of more precise and effective treatments. As research in this field advances, several emerging drugs appear promising for future investigation. While current findings are encouraging, further clinical studies are required to validate the therapeutic potential of these agents in kidney diseases, ultimately paving the way for more targeted and efficacious interventions.

Keywords: Autophagy; caloric restriction; inflammaging; kidney diseases; metabolic dysregulation; oxidative stress; senescence; senolytics.

Publication types

  • Review

MeSH terms

  • Aging / drug effects
  • Aging / physiology
  • Animals
  • Anti-Inflammatory Agents* / administration & dosage
  • Anti-Inflammatory Agents* / pharmacology
  • Autophagy / drug effects
  • Disease Progression
  • Drug Development*
  • Drugs, Investigational* / pharmacology
  • Humans
  • Inflammation* / drug therapy
  • Inflammation* / physiopathology
  • Kidney Diseases* / drug therapy
  • Kidney Diseases* / physiopathology
  • Longevity / drug effects
  • Oxidative Stress* / drug effects

Substances

  • Drugs, Investigational
  • Anti-Inflammatory Agents