Enteric fever is an endemic disease in developing and low-middle income countries due to poor sanitation and hygiene. The majority of cases have mild symptoms and resolve with oral or intravenous antibiotics. However, multisystemic involvement due to enteric fever requiring intensive care is not uncommon and is associated with high mortality and morbidity. We report a 5-year-old boy from Mohali, Punjab, India with enteric fever who had fulminant course with several complications including transient intussusception, myocardial dysfunction, encephalopathy, and secondary hemophagocytic lymphohistiocytosis. He was treated with ceftriaxone, vasoactive drugs, mechanical ventilation, dexamethasone, and intravenous immunoglobulin and had favorable outcome despite life-threatening complications.