Macrophages are dynamic and plastic immune cells essential for tissue homeostasis and pathogen defense. Their cell cycle regulation is highly influenced by intrinsic and extrinsic signals facilitating rapid responses to infections and tissue damage. Dysregulation of their cell cycle leads to diseases like cancer and HIV. This chapter highlights aspects of the macrophage cell cycle crucial for the development of targeted therapies.
Keywords: Cellular proliferation; Disease progression; Macrophage cell cycle; Molecular regulators; Plasticity.
© 2024. The Author(s), under exclusive license to Springer Nature Switzerland AG.