The discovery of the RCC1::IRF4 Fusion in CLL patients with t(1;6)(p35.3;p25.2) chromosomal translocation

Anna E Pula; Tadeusz Robak

doi:10.1111/bjh.19821

The discovery of the RCC1::IRF4 Fusion in CLL patients with t(1;6)(p35.3;p25.2) chromosomal translocation

Br J Haematol. 2024 Dec;205(6):2125-2127. doi: 10.1111/bjh.19821. Epub 2024 Oct 15.

Authors

Anna E Pula^{1

2}, Tadeusz Robak¹

Affiliations

¹ Department of Hematology, Medical University of Lodz, Lodz, Poland.
² Section of Hematology/Oncology, University of Chicago, Chicago, Illinois, USA.

PMID: 39410709
DOI: 10.1111/bjh.19821

Abstract

Jayne et al. provide a molecular characterization of the t(1;6)(p35.3;p25.2) chromosomal translocation in patients with chronic lymphocytic leukaemia. They indicate that this translocation involves the gene encoding interferon regulatory factor 4 (IRF4) on chromosome 6p25.2 with the regulator of chromosome condensation 1 (RCC1) gene on chromosome 1p35.3. This translocations may have important prognostic value. Commentary on: Jayne et al. The chromosomal translocation t(1;6)(p35.3;p25.2), recurrent in chronic lymphocytic leukaemia leads to RCC1::IRF4 fusion. Br J Haematol 2024; 205:2321-2326.

Keywords: RCC1::IRF4 fusion; chronic lymphocytic leukaemia; molecular characterization; t(1;6)(p35.3;p25.2).

MeSH terms

Cell Cycle Proteins* / genetics
Chromosomes, Human, Pair 1* / genetics
Chromosomes, Human, Pair 6* / genetics
Guanine Nucleotide Exchange Factors* / genetics
Humans
Interferon Regulatory Factors* / genetics
Leukemia, Lymphocytic, Chronic, B-Cell* / genetics
Nuclear Proteins / genetics
Oncogene Proteins, Fusion / genetics
Translocation, Genetic*

Substances

Interferon Regulatory Factors
interferon regulatory factor-4
Cell Cycle Proteins
Guanine Nucleotide Exchange Factors
RCC1 protein, human
Nuclear Proteins
Oncogene Proteins, Fusion