Mechanisms of RET-mediated signal transduction

Endocr Relat Cancer. 2024 Dec 13;32(1):e240131. doi: 10.1530/ERC-24-0131. Print 2025 Jan 1.

Abstract

The rearranged during transfection (RET) receptor tyrosine kinase is physiologically stimulated by growth factors belonging to the glial cell line-derived neurotrophic factor family and by the growth differentiation factor-15 cytokine. RET plays a critical role in normal development as well as in various human tumors and developmental disorders. This review focuses on mechanisms of RET signaling and their alterations in human diseases.

Keywords: cancer; growth factor; hereditary cancer; kinase; thyroid.

Publication types

  • Review

MeSH terms

  • Animals
  • Humans
  • Neoplasms / genetics
  • Neoplasms / metabolism
  • Proto-Oncogene Proteins c-ret* / genetics
  • Proto-Oncogene Proteins c-ret* / metabolism
  • Signal Transduction*

Substances

  • Proto-Oncogene Proteins c-ret
  • RET protein, human