Single-centre experience of implementing physiotherapist-led prehabilitation for chimeric antigen receptor T cell therapy

Introduction: This report outlines the evaluation of physiotherapist-led prehabilitation/rehabilitation for recipients of chimeric antigen receptor T (CAR-T) cell therapy.

Methods: A hybrid approach was used, incorporating in-person assessment of quality of life and functional capacity (6-min walk test and timed sit-to-stand test), and a personalised home exercise programme with remotely delivered physiotherapist support pre/post-admission.

Results: Functional deficits were prevalent at referral for CAR-T. Prehabilitation and rehabilitation were highly acceptable to patients, and improvements in functional capacity were documented pre-admission.

Conclusion: This data highlights the importance of pre-CAR-T functional assessment and prehabilitation to optimise preparation and recovery.