Extracorporeal cytokine adsorption as therapeutic option for immune effector cell-associated neurotoxicity syndrome

Neurol Sci. 2025 Jan;46(1):479-481. doi: 10.1007/s10072-024-07812-1. Epub 2024 Oct 17.

Abstract

With the rising number of patients receiving chimeric antigen receptor T-cells, the treatment of this therapy's complications is of growing concern to intensivists and neurologists. We used extracorporeal cytokine adsorption as an add-on therapy in a patient suffering from immune effector cell-associated neurotoxicity syndrome. Interleukin-6 level, which as a readily available parameter is generally used to evaluate course of disease, was rapidly reduced using this method. The patient made a full recovery and is still in hematological remission.

Keywords: Blood Purification; Clearance; Hemoperfusion; Removal.

Publication types

  • Case Reports

MeSH terms

  • Cytokines* / immunology
  • Female
  • Humans
  • Immunotherapy, Adoptive / adverse effects
  • Immunotherapy, Adoptive / methods
  • Interleukin-6 / immunology
  • Male
  • Neurotoxicity Syndromes* / etiology
  • Neurotoxicity Syndromes* / immunology

Substances

  • Cytokines
  • Interleukin-6
  • cell-associated neurotoxicity