Transcriptional memory formation: Battles between transcription factors and repressive chromatin

Zuodong Zhao; Bing Zhu

doi:10.1016/j.cels.2024.09.008

Transcriptional memory formation: Battles between transcription factors and repressive chromatin

Cell Syst. 2024 Oct 16;15(10):895-897. doi: 10.1016/j.cels.2024.09.008.

Authors

Zuodong Zhao¹, Bing Zhu²

Affiliations

¹ Key Laboratory of Epigenetic Regulation and Intervention, Institute of Biophysics, Chinese Academy of Sciences, Beijing 100101, China.
² Key Laboratory of Epigenetic Regulation and Intervention, Institute of Biophysics, Chinese Academy of Sciences, Beijing 100101, China; New Cornerstone Science Laboratory, Institute of Biophysics, Chinese Academy of Sciences, Beijing 100101, China; College of Life Sciences, University of Chinese Academy of Sciences, Beijing 100049, China. Electronic address: [email protected].

PMID: 39419001
DOI: 10.1016/j.cels.2024.09.008

Abstract

Transcriptional memory allows cells to respond to previously experienced signals in a faster, stronger, and more sensitive manner. Using synthetic biology approaches, Fan and colleagues uncovered the critical interplays between transcription factors and repressive chromatin in consolidating transcriptional memory.

MeSH terms

Animals
Chromatin* / genetics
Chromatin* / metabolism
Gene Expression Regulation / genetics
Humans
Transcription Factors* / genetics
Transcription Factors* / metabolism
Transcription, Genetic* / genetics

Substances

Chromatin
Transcription Factors