Nicotinate-Modified Lanthanide-Substituted Selenotungstate and Its Catalase-like Activity for the Detection of H2O2 and Ascorbic Acid

Lulu Liu; Limin Cui; Jun Jiang; Lijuan Chen; Junwei Zhao

doi:10.1021/acs.inorgchem.4c03165

Nicotinate-Modified Lanthanide-Substituted Selenotungstate and Its Catalase-like Activity for the Detection of H₂O₂ and Ascorbic Acid

Inorg Chem. 2024 Oct 18. doi: 10.1021/acs.inorgchem.4c03165. Online ahead of print.

Authors

Lulu Liu¹, Limin Cui¹, Jun Jiang¹, Lijuan Chen¹, Junwei Zhao¹

Affiliation

¹ Henan Key Laboratory of Polyoxometalate Chemistry, College of Chemistry and Molecular Sciences, Henan University, Kaifeng, Henan 475004, China.

PMID: 39423351
DOI: 10.1021/acs.inorgchem.4c03165

Abstract

A rigid nicotinate-modified lanthanide-substituted selenotungstate [H₂N(CH₃)₂]₆Na₃H[La₄SeW₈(H₂O)₁₆(nica)₂O₂₈][SeW₉O₃₃]₂·32H₂O (1, Hnica = nicotinic acid) was synthesized and consists of two trivacant Keggin [B-α-SeW₉O₃₃]^8- fragments and one unusual [SeW₄O₁₈]^8- fragment bridged by a heterometallic [La₄W₄(H₂O)₁₆(nica)₂O₂₈]^18- cluster. In the heterometallic cluster, two carboxyl O atoms in two nicotinate ligands directly coordinate with two W atoms in a stable C-O-W-O-W-O six-membered ring fashion. According to its catalase-like activity, 1 was utilized to catalyze the oxidation of 3,3',5,5'-tetramethylbenzidine (TMB) by H₂O₂ to produce blue oxidized TMB (ox-TMB), which can be used to establish a colorimetric sensing method for the detection of ascorbic acid. This work not only provides a promising platform for detecting H₂O₂ and ascorbic acid but also expands the application potential of polyoxometalate-based materials in biological and clinical analyses.