Bipolar disorder among individuals with atopic dermatitis: A case-control study in the All of Us Research Program

A Mitchel Wride; Gloria F Chen; Ryan Fan; Audrey C Leasure; S Scott Jones; Daniel F Levey; William Damsky; Jeffrey M Cohen

doi:10.1093/ced/llae451

Bipolar disorder among individuals with atopic dermatitis: A case-control study in the All of Us Research Program

Clin Exp Dermatol. 2024 Oct 19:llae451. doi: 10.1093/ced/llae451. Online ahead of print.

Authors

A Mitchel Wride¹, Gloria F Chen¹, Ryan Fan¹, Audrey C Leasure², S Scott Jones³, Daniel F Levey^{4

5}, William Damsky^{5

6}, Jeffrey M Cohen^{2

7}

Affiliations

¹ Yale School of Medicine, New Haven, CT, USA.
² Department of Dermatology, Yale School of Medicine, New Haven, CT, USA.
³ Feinstein Institutes for Medical Research, Northwell Health, Manhasset, NY, USA.
⁴ Department of Psychiatry, Yale School of Medicine, West Haven, CT, USA.
⁵ Veterans Affairs Connecticut Healthcare Center, West Haven, CT, USA.
⁶ Department of Pathology, Yale School of Medicine, New Haven, CT, USA.
⁷ Section of Biomedical Informatics and Data Science, Yale School of Medicine, New Haven, CT, USA.

PMID: 39425681
DOI: 10.1093/ced/llae451

Abstract

Background: Atopic dermatitis (AD) has been associated with psychiatric comorbidities.

Objectives: To characterize the association between AD and bipolar disorder (BPD) with a case-control study of the NIH All of Us Research Program.

Methods: Utilizing Systemized Nomenclature of Medicine diagnostic codes, we identified cases of AD. Four age, sex, and race/ethnicity matched controls were found for each case using propensity score matching. After controlling for age, sex, race/ethnicity, income, smoking status, and depression, the relationship between AD and BPD was evaluated using logistic regression.

Results: We identified 13,431 AD cases with 53,724 matched controls. Participants with AD were more likely than controls to have BPD (7.8% vs. 4.6%, P<.001). After adjusting for demographics and comorbidities, we observed a significant association (OR 1.49, 95%CI 1.37-1.62, P<.001).

Conclusion: Compared to individuals without AD, individuals with AD have 1.49-fold increased odds of having BPD. Further investigation is needed to further understand this association.

© The Author(s) 2024. Published by Oxford University Press on behalf of British Association of Dermatologists. All rights reserved. For commercial re-use, please contact [email protected] for reprints and translation rights for reprints. All other permissions can be obtained through our RightsLink service via the Permissions link on the article page on our site—for further information please contact [email protected].