Human midbrain organoids: a powerful tool for advanced Parkinson's disease modeling and therapy exploration

Xin Cui; Xinwei Li; Huimin Zheng; Yun Su; Shuyu Zhang; Mengjie Li; Xiaoyan Hao; Shuo Zhang; Zhengwei Hu; Zongping Xia; Changhe Shi; Yuming Xu; Chengyuan Mao

doi:10.1038/s41531-024-00799-8

Human midbrain organoids: a powerful tool for advanced Parkinson's disease modeling and therapy exploration

NPJ Parkinsons Dis. 2024 Oct 20;10(1):189. doi: 10.1038/s41531-024-00799-8.

Authors

Xin Cui^#^{1

2

3}, Xinwei Li^#^{1

2

3}, Huimin Zheng^#^{1

3}, Yun Su^#^{1

3}, Shuyu Zhang^{1

4}, Mengjie Li^{1

3}, Xiaoyan Hao^{1

3}, Shuo Zhang^{1

2

3}, Zhengwei Hu^{1

2

3}, Zongping Xia^{1

3

5}, Changhe Shi^{1

3

6}, Yuming Xu^{7

8

9}, Chengyuan Mao^{10

11}

Affiliations

¹ Department of Neurology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou University, Zhengzhou, China.
² Academy of Medical Sciences of Zhengzhou University, Zhengzhou, China.
³ Henan Key Laboratory of Cerebrovascular Diseases, The First Affiliated Hospital of Zhengzhou University, Zhengzhou University, Zhengzhou, China.
⁴ Neuro-Intensive Care Unit, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.
⁵ Clinical Systems Biology Laboratories, Zhengzhou University, Zhengzhou, China.
⁶ Institute of Neuroscience, Zhengzhou University, Zhengzhou, China.
⁷ Department of Neurology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou University, Zhengzhou, China. [email protected].
⁸ Henan Key Laboratory of Cerebrovascular Diseases, The First Affiliated Hospital of Zhengzhou University, Zhengzhou University, Zhengzhou, China. [email protected].
⁹ Institute of Neuroscience, Zhengzhou University, Zhengzhou, China. [email protected].
¹⁰ Department of Neurology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou University, Zhengzhou, China. [email protected].
¹¹ Henan Key Laboratory of Cerebrovascular Diseases, The First Affiliated Hospital of Zhengzhou University, Zhengzhou University, Zhengzhou, China. [email protected].

^# Contributed equally.

PMID: 39428415
DOI: 10.1038/s41531-024-00799-8

Abstract

Parkinson's disease (PD) is a neurodegenerative disorder marked by the loss of dopaminergic neurons in the substantia nigra. Despite progress, the pathogenesis remains unclear. Human midbrain organoids (hMLOs) have emerged as a promising model for studying PD, drug screening, and potential treatments. This review discusses the development of hMLOs, their application in PD research, and current challenges in organoid construction, highlighting possible optimization strategies.

Publication types

Review

Grants and funding

82271277/National Natural Science Foundation of China (National Science Foundation of China)