The Effects of Early Life History of TBI on the Progression of Normal Brain Aging with Implications for Increased Dementia Risk

Makenna B McGill; David M Schnyer

doi:10.1007/978-3-031-69832-3_6

The Effects of Early Life History of TBI on the Progression of Normal Brain Aging with Implications for Increased Dementia Risk

Adv Neurobiol. 2024:42:119-143. doi: 10.1007/978-3-031-69832-3_6.

Authors

Makenna B McGill¹, David M Schnyer²

Affiliations

¹ Department of Psychology, The University of Texas at Austin, Austin, TX, USA. [email protected].
² Department of Psychology, The University of Texas at Austin, Austin, TX, USA.

PMID: 39432040
DOI: 10.1007/978-3-031-69832-3_6

Abstract

There is increasing interest in the risk conferred on neurological health by a traumatic brain injury (TBI) and how that influences the lifespan trajectory of brain aging. This chapter explores the importance of this issue, population, and methodological considerations, including injury documentation and outcome assessment. We then explore some of the findings in the neuroimaging and neuropsychological research literature examining the interaction between an earlier life history of TBI and the normal aging process. Finally, we consider the limitations of our current knowledge and where the field needs to go in the future.

Keywords: Aging; Dementia risk; Neuroimaging; Traumatic brain injury.

Publication types

Review

MeSH terms

Aging* / physiology
Brain Injuries, Traumatic* / physiopathology
Brain* / diagnostic imaging
Brain* / physiopathology
Dementia* / epidemiology
Dementia* / physiopathology
Disease Progression
Humans
Neuroimaging
Risk Factors