The roles of DNA damage repair and innate immune surveillance pathways in HPV pathogenesis

Takeyuki Kono; Hiroyuki Ozawa; Laimonis Laimins

doi:10.1016/j.virol.2024.110266

The roles of DNA damage repair and innate immune surveillance pathways in HPV pathogenesis

Virology. 2024 Dec:600:110266. doi: 10.1016/j.virol.2024.110266. Epub 2024 Oct 18.

Authors

Takeyuki Kono¹, Hiroyuki Ozawa², Laimonis Laimins³

Affiliations

¹ Dept of Otolaryngology-Head Neck Surgery, Keio University, School of Medicine, Tokyo, Japan; Dept of Microbiology-Immunology, Northwestern University, Chicago, IL, 60611, USA.
² Dept of Otolaryngology-Head Neck Surgery, Keio University, School of Medicine, Tokyo, Japan.
³ Dept of Microbiology-Immunology, Northwestern University, Chicago, IL, 60611, USA. Electronic address: [email protected].

PMID: 39433009
DOI: 10.1016/j.virol.2024.110266

Abstract

Human papillomaviruses (HPV) infect epithelial tissues and induce a variety of proliferative lesions. A subset of HPV types are also the causative agents of many anogenital as well as oropharyngeal cancers. Following infection of basal epithelial cells, HPVs establish their genomes as episomes in undifferentiated cells and require differentiation for their productive life cycles. During HPV infections, viral oncoproteins alter cellular pathways such as those for DNA damage repair and innate immune surveillances to regulate their productive life cycles. These pathways provide potential targets for therapeutic intervention.

Keywords: ATM; ATR; DNA damage repair; Differentiation; Innate immune surveillance; Life cycle; Papillomaviruses.

Publication types

Review

MeSH terms

DNA Damage
DNA Repair*
Host-Pathogen Interactions / immunology
Humans
Immunity, Innate*
Papillomaviridae* / genetics
Papillomaviridae* / immunology
Papillomaviridae* / pathogenicity
Papillomaviridae* / physiology
Papillomavirus Infections* / immunology
Papillomavirus Infections* / virology