Chemical mechanisms describe how emissions of gases and particles evolve in the atmosphere and are used within chemical transport models to evaluate past, current, and future air quality. Thus, a chemical mechanism must provide robust and accurate predictions of air pollutants if it is to be considered for use by regulatory bodies. In this work, we provide an initial evaluation of the Community Regional Atmospheric Chemistry Multiphase Mechanism (CRACMMv1.0) by assessing CRACMMv1.0 predictions of surface ozone (O3) across the northeastern US during the summer of 2018 within the Community Multiscale Air Quality (CMAQ) modeling system. CRACMMv1.0 O3 predictions of hourly and maximum daily 8 h average (MDA8) ozone were lower than those estimated by the Regional Atmospheric Chemistry Mechanism with aerosol module 6 (RACM2_ae6), which better matched surface network observations in the northeastern US (RACM2_ae6 mean bias of +4.2 ppb for all hours and +4.3 ppb for MDA8; CRACMMv1.0 mean bias of +2.1 ppb for all hours and +2.7 ppb for MDA8). Box model calculations combined with results from CMAQ emission reduction simulations indicated a high sensitivity of O3 to compounds with biogenic sources. In addition, these calculations indicated the differences between CRACMMv1.0 and RACM2_ae6 O3 predictions were largely explained by updates to the inorganic rate constants (reflecting the latest assessment values) and by updates to the representation of monoterpene chemistry. Updates to other reactive organic carbon systems between RACM2_ae6 and CRACMMv1.0 also affected ozone predictions and their sensitivity to emissions. Specifically, CRACMMv1.0 benzene, toluene, and xylene chemistry led to efficient NO x cycling such that CRACMMv1.0 predicted controlling aromatics reduces ozone without rural O3 disbenefits. In contrast, semivolatile and intermediate-volatility alkanes introduced in CRACMMv1.0 acted to suppress O3 formation across the regional background through the sequestration of nitrogen oxides (NO x ) in organic nitrates. Overall, these analyses showed that the CRACMMv1.0 mechanism within the CMAQ model was able to reasonably simulate ozone concentrations in the northeastern US during the summer of 2018 with similar magnitude and diurnal variation as the current operational Carbon Bond (CB6r3_ae7) mechanism and good model performance compared to recent modeling studies in the literature.