Genetic characterization and receptor binding analysis of a novel H5N1 HPAI virus with a H6Nx-derived PA gene in Guangdong, China

Jieheng He; Jing Liu; Zhanfei Yan; Gaojie Chen; Runzhi Liu; Yu Yang; Yulin Yan; Sheng Yuan; Jinyue Guo; Yong Li; Hai Yu; Zhaoping Liang; Tao Ren; Shujian Huang; Feng Wen

doi:10.1080/22221751.2024.2417857

Genetic characterization and receptor binding analysis of a novel H5N1 HPAI virus with a H6Nx-derived PA gene in Guangdong, China

Emerg Microbes Infect. 2024 Dec;13(1):2417857. doi: 10.1080/22221751.2024.2417857. Epub 2024 Nov 4.

Authors

Jieheng He¹, Jing Liu¹, Zhanfei Yan¹, Gaojie Chen¹, Runzhi Liu¹, Yu Yang¹, Yulin Yan¹, Sheng Yuan¹, Jinyue Guo¹, Yong Li², Hai Yu³, Zhaoping Liang⁴, Tao Ren⁴, Shujian Huang¹, Feng Wen¹

Affiliations

¹ College of Animal Science and Technology, Foshan University, No. 33 Guangyun Road, Shishan Town, Nanhai District, 528231, Foshan, Guangdong, People's Republic of China.
² College of Animal Science and Technology, Jiangxi Agricultural University, Nanchang, Jiangxi, People's Republic of China.
³ Shanghai Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Shanghai, People's Republic of China.
⁴ College of Veterinary Medicine, South China Agricultural University, Guangzhou, Guangdong, People's Republic of China.

No abstract available

Keywords: Avian influenza virus (AIV); H5N1; H6 subtype; PA gene; highly pathogenic avian influenza virus (HPAIV).

Grants and funding

This work was supported by Basic and Applied Basic Research Foundation of Guangdong Province: [Grant Number 2024A1515010836]; National Natural Science Foundation of China: [Grant Number 32002320]; Research Project of Education Department of Guangdong Province, China: [Grant Number 2022KTSCX124]; Guangzhou Zengcheng District Entrepreneurship Leading Team Project: [Grant Number 202101001].