Aging and senescent fates of oligodendrocyte precursor cells in the mouse brain

Paul T Gomez; Chase M Carver; Sonia L Rodriguez; Liguo Wang; Xu Zhang; Marissa J Schafer

doi:10.1038/s41514-024-00176-y

Aging and senescent fates of oligodendrocyte precursor cells in the mouse brain

NPJ Aging. 2024 Oct 22;10(1):47. doi: 10.1038/s41514-024-00176-y.

Authors

Paul T Gomez^{1

2}, Chase M Carver^{1

2}, Sonia L Rodriguez^{1

2}, Liguo Wang³, Xu Zhang^{1

4}, Marissa J Schafer^{5

6

7

8}

Affiliations

¹ Robert and Arlene Kogod Center on Aging, Mayo Clinic, Rochester, MN, USA.
² Department of Physiology and Biomedical Engineering, Mayo Clinic, Rochester, MN, USA.
³ Division of Computational Biology, Mayo Clinic College of Medicine, Rochester, MN, USA.
⁴ Department of Biochemistry and Molecular Biology, Mayo Clinic, Rochester, MN, USA.
⁵ Robert and Arlene Kogod Center on Aging, Mayo Clinic, Rochester, MN, USA. [email protected].
⁶ Department of Physiology and Biomedical Engineering, Mayo Clinic, Rochester, MN, USA. [email protected].
⁷ Department of Neurology, Mayo Clinic, Rochester, MN, USA. [email protected].
⁸ Department of Neuroscience, Mayo Clinic, Rochester, MN, USA. [email protected].

Abstract

Age-related changes in oligodendrocyte precursor cells (OPCs) contribute to white matter dysfunction. In aged mice, we hypothesized that myelin-dense fimbria OPCs possess niche-specific properties, compared to hippocampal OPCs. Aged fimbria OPCs were fewer, larger, and localized to neighboring microglia. We identified age-increased p16/Cdkn2a-expressing OPCs enriched for senescence-related pathways and distinct senescence signatures between hippocampus and fimbria. Aged brain OPC populations differ in microenvironment properties and responses to senescence-directed intervention.

Abstract

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