In this paper, we report a short and efficient synthesis of novel N-arylbenzo[h]quinazoline-2-amines. We have prepared a focused library of nineteen representative examples which have been submitted to cytotoxicity assays against a representative panel of eight cancer cell lines and several molecules gave attractive results in this area.
Keywords: Buchwald–Hartwig coupling; Pd catalysis; cytotoxicity; heterocycles; quinazolines.
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