We report a case of persistent disseminated mpox evolving over >6 months in an HIV/hepatitis B virus co-infected patient in France who had <200 CD4+ cells/mm3, pulmonary and hepatic necrotic lesions, persistent viremia, and nasopharyngeal excretion. Clinical outcome was favorable after 90 days of tecovirimat treatment and administration of human vaccinia immunoglobulins.
Keywords: France; HBV; HIV; HIV/AIDS and other retroviruses; VIGIV; hepatitis B virus; human vaccinia immune globulins; liver; liver abscess; lungs; monkeypox virus; mpox; necrotic lesions; sexually transmitted infections; tecovirimat; vaccinia immune globulins intravenous; viruses; zoonoses.