Cardiomyopathies: The Role of Non-Coding RNAs

Noncoding RNA. 2024 Oct 23;10(6):53. doi: 10.3390/ncrna10060053.

Abstract

Cardiomyopathies are the structural and functional disorders of the myocardium. Etiopathogenesis is complex and involves an interplay of genetic, environmental, and lifestyle factors eventually leading to myocardial abnormalities. It is known that non-coding (Nc) RNAs, including micro (mi)-RNAs and long non-coding (lnc) RNAs, play a crucial role in regulating gene expression. Several studies have explored the role of miRNAs in the development of various pathologies, including heart diseases. In this review, we analyzed various patterns of ncRNAs expressed in the most common cardiomyopathies: dilated cardiomyopathy, hypertrophic cardiomyopathy and arrhythmogenic cardiomyopathy. Understanding the role of different ncRNAs implicated in cardiomyopathic processes may contribute to the identification of potential therapeutic targets and novel risk stratification models based on gene expression. The analysis of ncRNAs may also be helpful to unveil the molecular mechanisms subtended to these diseases.

Keywords: cardiomyopathies; long non-coding RNAs; micro-RNAs; non-coding RNAs.

Publication types

  • Review

Grants and funding

This work was supported by grants from the Italian Ministry of University and Research (PNRR-National Center for Gene Therapy and Drugs based on RNA Technology CN00000041; PRIN P2022W577H_001: CUP F53D23011320001), and from the Italian Ministry of Health (PSC SALUTE 2014–2020-POS4 “Cal-HubRia”-T4-AN-09 and PNRR-MAD-2022-12376814.