Recovery and partial isolation of ⍺-mangostin from mangosteen pericarpsvia sequential extraction and precipitation

PLoS One. 2024 Oct 25;19(10):e0310453. doi: 10.1371/journal.pone.0310453. eCollection 2024.

Abstract

This study introduced an innovative sequential extraction methodology designed for the efficient recovery of alpha-mangostin (⍺-M) from mangosteen pericarps. Alpha-mangostin, renowned for its pharmacological properties including anti-inflammatory, anti-cancer, and anti-bacterial effects, has garnered significant attention across diverse industries. The proposed method of sequential extraction achieved 73% recovery and a yield of 46.75 mg/g based on the weight/weight percentage of the mass of ⍺-M extracted from the sequence and the mass of raw material. Furthermore, the purity of the dried product was 67.9%. The sequence solvent extraction system, comprising water, hexane, and acetonitrile, plays a pivotal role in enhancing the efficacy of the extraction process. Notably, this methodology offers a cost-effective alternative to conventional extraction methods. It reduces the need for complex equipment and processes, positioning it as a resource-efficient extraction technique in comparison to existing methodologies. This novel sequential extraction method presents a promising avenue for the economical and sustainable recovery of alpha-mangostin (⍺-M) from pericarps.

MeSH terms

  • Chemical Precipitation
  • Garcinia mangostana* / chemistry
  • Plant Extracts / chemistry
  • Plant Extracts / isolation & purification
  • Plant Extracts / pharmacology
  • Solvents / chemistry
  • Xanthones* / chemistry
  • Xanthones* / isolation & purification
  • Xanthones* / pharmacology

Substances

  • Xanthones
  • mangostin
  • Plant Extracts
  • Solvents

Grants and funding

This work was supported by the Faculty of Engineering, Kasetsart University. The funder had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.