Optimizing chemically stable chloramphenicol in-situ gel formulations using poloxamer 407 and HPMC through full-factorial design

Sci Rep. 2024 Oct 25;14(1):25344. doi: 10.1038/s41598-024-74945-w.

Abstract

The primary goal was to enhance the stability and bioavailability of chloramphenicol for ophthalmic use without compromising patient comfort, such as causing blurry vision. This study employed a 2-level full factorial design to optimize the formulation, exploring different concentrations of poloxamer 407 and HPMC to achieve this objective.

Keywords: In-situ gel; Desirability; Full-factorial design; HPMC; Ophthalmic; Poloxamer 407.

MeSH terms

  • Anti-Bacterial Agents / chemistry
  • Anti-Bacterial Agents / pharmacokinetics
  • Biological Availability
  • Chemistry, Pharmaceutical / methods
  • Chloramphenicol* / chemistry
  • Drug Compounding / methods
  • Drug Stability
  • Gels* / chemistry
  • Humans
  • Hypromellose Derivatives* / chemistry
  • Poloxamer* / chemistry

Substances

  • Chloramphenicol
  • Poloxamer
  • Hypromellose Derivatives
  • Gels
  • Anti-Bacterial Agents