Advancing Treatment Options for Merkel Cell Carcinoma: A Review of Tumor-Targeted Therapies

Int J Mol Sci. 2024 Oct 15;25(20):11055. doi: 10.3390/ijms252011055.

Abstract

Although rare, Merkel cell carcinoma (MCC) is a highly aggressive and increasingly prevalent neuroendocrine cancer of the skin. While current interventions, including surgical resection, radiation, and immunotherapy have been employed in treating many patients, those who remain unresponsive to treatment are met with sparse alternatives and a grim prognosis. For this reason, it is of interest to expand the repertoire of available therapies for MCC patients who remain resistant to current primary interventions. Recently, our improved mechanistic understanding of aberrant cell signaling observed in both MCPyV-positive and -negative MCC has facilitated exploration into several small molecules and inhibitors, among them receptor tyrosine kinase inhibitors (TKIs) and somatostatin analogs (SSAs), both of which have positively improved response rates and reduced tumor volumes upon application to treatment of MCC. The introduction of such targeted therapies into treatment protocols holds promise for more personalized care tailored towards patients of diverse subtypes, thereby improving outcomes and mitigating tumor burden, especially for treatment-resistant individuals. In this review, we characterize recent findings surrounding targeted treatments that have been applied to MCC and provide an overview of emerging perspectives on translatable options that can be further developed to offer additional therapeutic avenues for patients with the disease.

Keywords: Merkel cell carcinoma; clinical trials; receptor tyrosine kinase inhibitors; somatostatin analogs; targeted therapies.

Publication types

  • Review

MeSH terms

  • Antineoplastic Agents / therapeutic use
  • Carcinoma, Merkel Cell* / drug therapy
  • Carcinoma, Merkel Cell* / pathology
  • Carcinoma, Merkel Cell* / therapy
  • Humans
  • Molecular Targeted Therapy* / methods
  • Protein Kinase Inhibitors / therapeutic use
  • Skin Neoplasms* / drug therapy
  • Skin Neoplasms* / pathology
  • Skin Neoplasms* / therapy

Substances

  • Protein Kinase Inhibitors
  • Antineoplastic Agents

Grants and funding

This research received no external funding.