From Bench to Bedside: A Team's Approach to Multidisciplinary Strategies to Combat Therapeutic Resistance in Head and Neck Squamous Cell Carcinoma

Bridget E Crossman; Regan L Harmon; Kourtney L Kostecki; Nellie K McDaniel; Mari Iida; Luke W Corday; Christine E Glitchev; Madisen T Crow; Madelyn A Harris; Candie Y Lin; Jillian M Adams; Colin A Longhurst; Kwangok P Nickel; Irene M Ong; Roxana A Alexandridis; Menggang Yu; David T Yang; Rong Hu; Zachary S Morris; Gregory K Hartig; Tiffany A Glazer; Sravani Ramisetty; Prakash Kulkarni; Ravi Salgia; Randall J Kimple; Justine Y Bruce; Paul M Harari; Deric L Wheeler

doi:10.3390/jcm13206036

From Bench to Bedside: A Team's Approach to Multidisciplinary Strategies to Combat Therapeutic Resistance in Head and Neck Squamous Cell Carcinoma

J Clin Med. 2024 Oct 10;13(20):6036. doi: 10.3390/jcm13206036.

Authors

Bridget E Crossman¹, Regan L Harmon¹, Kourtney L Kostecki¹, Nellie K McDaniel¹, Mari Iida¹, Luke W Corday¹, Christine E Glitchev¹, Madisen T Crow¹, Madelyn A Harris¹, Candie Y Lin¹, Jillian M Adams¹, Colin A Longhurst², Kwangok P Nickel¹, Irene M Ong^{2

3

4}, Roxana A Alexandridis², Menggang Yu⁵, David T Yang⁶, Rong Hu^{3

6}, Zachary S Morris¹, Gregory K Hartig⁷, Tiffany A Glazer⁷, Sravani Ramisetty⁸, Prakash Kulkarni⁸, Ravi Salgia⁸, Randall J Kimple^{1

3}, Justine Y Bruce^{3

9}, Paul M Harari^{1

3}, Deric L Wheeler^{1

3}

Affiliations

¹ Department of Human Oncology, University of Wisconsin, Madison, WI 53705, USA.
² Departments of Biostatistics and Medical Informatics, University of Wisconsin, Madison, WI 53726, USA.
³ Carbone Cancer Center, University of Wisconsin, Madison, WI 53792, USA.
⁴ Department of Obstetrics and Gynecology, University of Wisconsin, Madison, WI 53705, USA.
⁵ Department of Biostatistics, University of Michigan, Ann Arbor, MI 48109, USA.
⁶ Department of Pathology and Laboratory Medicine, University of Wisconsin, Madison, WI 53705, USA.
⁷ Department of Surgery, University of Wisconsin, Madison, WI 53705, USA.
⁸ Department of Medical Oncology and Therapeutics Research, City of Hope Comprehensive Cancer Center, Duarte, CA 91010, USA.
⁹ Department of Medicine, University of Wisconsin, Madison, WI 53705, USA.

Abstract

Head and neck squamous cell carcinoma (HNSCC) is diagnosed in more than 71,000 patients each year in the United States, with nearly 16,000 associated deaths. One significant hurdle in the treatment of HNSCC is acquired and intrinsic resistance to existing therapeutic agents. Over the past several decades, the University of Wisconsin has formed a multidisciplinary team to move basic scientific discovery along the translational spectrum to impact the lives of HNSCC patients. In this review, we outline key discoveries made throughout the years at the University of Wisconsin to deepen our understanding of therapeutic resistance in HNSCC and how a strong, interdisciplinary team can make significant advances toward improving the lives of these patients by combatting resistance to established therapeutic modalities. We are profoundly grateful to the many scientific teams worldwide whose groundbreaking discoveries, alongside evolving clinical paradigms in head and neck oncology, have been instrumental in making our work possible.

Keywords: Axl; EGFR; HNSCC; MerTK; TAMs; cetuximab; resistance.

Publication types

Review

Abstract

Publication types

Grants and funding