Non-coding RNAs: Key regulators of CDK and Wnt/β-catenin signaling in cancer

Mohammad Arshad Javed Shaikh; M Arockia Babu; Nehmat Ghaboura; Abdulmalik S A Altamimi; Pawan Sharma; Richa Rani; G B Rani; Sorabh Lakhanpal; Haider Ali; Ashok Kumar Balaraman; Sushama Rawat; Sami I Alzarea; Imran Kazmi

doi:10.1016/j.prp.2024.155659

Non-coding RNAs: Key regulators of CDK and Wnt/β-catenin signaling in cancer

Pathol Res Pract. 2024 Oct 15:263:155659. doi: 10.1016/j.prp.2024.155659. Online ahead of print.

Authors

Affiliations

¹ Department of Pharmacy, TPCT's College of Engineering, Osmanabad, Maharashtra, India.
² Institute of Pharmaceutical Research, GLA UNIVERSITY, Mathura, UP 281406, India.
³ Department of Pharmaceutical Chemistry, College of Pharmacy, Prince Sattam Bin Abdulaziz University, Al Kharj 11942, Saudi Arabia.
⁴ Department of Pharmacy Practice, Pharmacy Program, Batterjee Medical College, P. O. Box 6231, Jeddah 21442, Saudi Arabia.
⁵ Department of Allied Healthcare and Sciences, Vivekananda Global University, Jaipur, Rajasthan 303012, India. Electronic address: [email protected].
⁶ University Centre for Research and Development, Chandigarh University, Mohali, Punjab 140413, India.
⁷ KKR and KSR Institute of Technology and Sciences, Guntur, India.
⁸ Division of Research and Development, Lovely Professional University, Phagwara 144411, India.
⁹ Centre for Global Health Research, Saveetha Medical College, Saveetha Institute of Medical and Technical Sciences, India; Department of Pharmacology, Kyrgyz State Medical College, Bishkek, Kyrgyzstan.
¹⁰ Research and Enterprise, University of Cyberjaya, Persiaran Bestari, Cyber 11, Cyberjaya, Selangor 63000, Malaysia.
¹¹ Graphic Era (Deemed to be University), Clement Town, Dehradun 248002, India.
¹² Department of Pharmacology, College of Pharmacy, Jouf University, Sakaka, Al-Jouf 72341, Saudi Arabia.
¹³ Department of Biochemistry, Faculty of Science, King Abdulaziz University, Jeddah 21589, Saudi Arabia.

PMID: 39461246
DOI: 10.1016/j.prp.2024.155659

Abstract

Non-coding RNAs (ncRNAs) have become important modulators of gene expression and biological processes, contributing significantly to the initiation and spread of cancer. This study focuses on the complex interactions between ncRNAs and two major signaling pathways-Wnt/β-catenin signaling and cyclin-dependent kinase (CDK)-linked to cancer. We provide an overview of current research on the modulation of these pathways in many cancer types by distinct classes of ncRNAs, such as miRNAs, lncRNAs, and circRNAs. The review focuses on the processes by which ncRNAs regulate cancer cell survival, proliferation, and metastasis. These mechanical processes include CDK activity, the activation of the Wnt/β-catenin cascade and cell cycle advancement. We also discuss the importance of ncRNAs in drug resistance and treatment outcomes, as well as prognosis markers (diagnostic) and therapeutic targets for cancer. Understanding these complex regulatory networks may help in a large way to improve cancer research and diagnosis - but also perhaps treat patients more effectively.

Keywords: Cyclin-dependent kinase; Gene expression; NcRNAs; Prognosis markers; Wnt/β-catenin.

Publication types

Review