Effect of Statin Treatment on Lipoprotein-Associated Phospholipase A2 Mass and Activity: A Systematic Review and Meta-analysis of Randomized Placebo-Controlled Trials

Amirhossein Sahebkar; Željko Reiner; Wael Almahmeed; Tannaz Jamialahmadi; Luis E Simental-Mendía

doi:10.1007/s10557-024-07634-5

Effect of Statin Treatment on Lipoprotein-Associated Phospholipase A2 Mass and Activity: A Systematic Review and Meta-analysis of Randomized Placebo-Controlled Trials

Cardiovasc Drugs Ther. 2024 Oct 28. doi: 10.1007/s10557-024-07634-5. Online ahead of print.

Authors

Amirhossein Sahebkar^{1

2

3}, Željko Reiner^{4

5}, Wael Almahmeed⁶, Tannaz Jamialahmadi^{7

8}, Luis E Simental-Mendía⁹

Affiliations

¹ Center for Global Health Research, Saveetha Medical College and Hospitals, Saveetha Institute of Medical and Technical Sciences, Saveetha University, Chennai, India.
² Applied Biomedical Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.
³ Biotechnology Research Center, Pharmaceutical Technology Institute, Mashhad University of Medical Sciences, Mashhad, Iran.
⁴ Department of Internal Medicine, University Hospital Center Zagreb, University of Zagreb, Kišpatićeva 12, Zagreb, Croatia.
⁵ Polish Mother's Memorial Hospital Research Institute, Lodz, 93-338, Poland.
⁶ Heart and Vascular Institute, Cleveland Clinic Abu Dhabi, Abu Dhabi, United Arab Emirates.
⁷ Pharmaceutical Research Center, Pharmaceutical Technology Institute, Mashhad University of Medical Sciences, Mashhad, Iran.
⁸ Medical Toxicology Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.
⁹ Unidad de Investigación Biomédica, Delegación Durango, Instituto Mexicano del Seguro Social, Durango, Mexico. [email protected].

PMID: 39466484
DOI: 10.1007/s10557-024-07634-5

Abstract

Purpose: The goal of this meta-analysis was to establish whether statin treatment reduces Lp-PLA2 mass concentration and/or activity.

Methods: PubMed, Scopus, Web of Science, ClinicalTrials.gov, and Google Scholar databases were searched using MESH terms and keywords. Randomized controlled trials (RCT) with either parallel or cross-over design examining the effect of statins on Lp-PLA2 mass and/or activity were included in meta-analysis.

Results: Out of 256 articles, 10 RCT were selected for meta-analysis. Statin therapy significantly reduced both Lp-PLA2 mass (WMD -44.46 ng/mL; 95%CI -59.01, -29.90; p < 0.001; I² = 93%) and activity (WMD -39.37 nmol/min/mL; 95%CI -69.99, -8.75; p = 0.01; I² = 100%). The sensitivity analysis was robust for Lp-PLA2 mass and was also positive for two studies concerning Lp-PLA2 activity.

Conclusion: Statin therapy significantly reduced both Lp-PLA2 mass and activity.

Keywords: Cardiovascular disease; Coronary heart disease; Ischemic stroke; Lipoprotein-associated phospholipase A2; Statins.

Publication types

Review