The Significance of Comprehensive Metabolic Phenotypes in Cancer Risk: A Japan Multi-Institutional Collaborative Cohort Study

Takeshi Watanabe; Tien Van Nguyen; Sakurako Katsuura-Kamano; Kokichi Arisawa; Masashi Ishizu; Taichi Unohara; Keitaro Tanaka; Chisato Shimanoe; Mako Nagayoshi; Takashi Tamura; Yuko Kubo; Yasufumi Kato; Isao Oze; Hidemi Ito; Nobuaki Michihata; Yohko Nakamura; Shiroh Tanoue; Chihaya Koriyama; Sadao Suzuki; Hiroko Nakagawa-Senda; Teruhide Koyama; Satomi Tomida; Kiyonori Kuriki; Naoyuki Takashima; Akiko Harada; Kenji Wakai; Keitaro Matsuo; J-MICC Study Group

doi:10.1158/2767-9764.CRC-24-0249

The Significance of Comprehensive Metabolic Phenotypes in Cancer Risk: A Japan Multi-Institutional Collaborative Cohort Study

Cancer Res Commun. 2024 Nov 1;4(11):2986-2997. doi: 10.1158/2767-9764.CRC-24-0249.

Authors

Takeshi Watanabe^#¹, Tien Van Nguyen^#^{1

2}, Sakurako Katsuura-Kamano^{1

3}, Kokichi Arisawa¹, Masashi Ishizu¹, Taichi Unohara^{1

4}, Keitaro Tanaka⁵, Chisato Shimanoe⁶, Mako Nagayoshi⁷, Takashi Tamura⁷, Yuko Kubo⁷, Yasufumi Kato⁷, Isao Oze⁸, Hidemi Ito⁹, Nobuaki Michihata^{10

11}, Yohko Nakamura¹¹, Shiroh Tanoue¹², Chihaya Koriyama¹², Sadao Suzuki¹³, Hiroko Nakagawa-Senda¹³, Teruhide Koyama¹⁴, Satomi Tomida^{14

15}, Kiyonori Kuriki¹⁶, Naoyuki Takashima^{14

17}, Akiko Harada¹⁷, Kenji Wakai⁷, Keitaro Matsuo^{8

18}; J-MICC Study Group

Affiliations

¹ Department of Preventive Medicine, Tokushima University Graduate School of Biomedical Sciences, Tokushima, Japan.
² Thai Binh University of Medicine and Pharmacy, Thai Binh, Vietnam.
³ Department of Food Nutritional Science, Tokushima Bunri University, Tokushima, Japan.
⁴ Student Lab, Tokushima University Faculty of Medicine, Tokushima, Japan.
⁵ Department of Preventive Medicine, Faculty of Medicine, Saga University, Saga, Japan.
⁶ Department of Pharmacy, Saga University Hospital, Saga, Japan.
⁷ Department of Preventive Medicine, Nagoya University Graduate School of Medicine, Nagoya, Japan.
⁸ Division of Cancer Epidemiology and Prevention, Aichi Cancer Center Research Institute, Nagoya, Japan.
⁹ Division of Cancer Information and Control, Aichi Cancer Center Research Institute, Nagoya, Japan.
¹⁰ Department of Descriptive Cancer Epidemiology, Nagoya University Graduate School of Medicine, Nagoya, Japan.
¹¹ Cancer Prevention Center, Chiba Cancer Center Research Institute, Chiba, Japan.
¹² Department of Epidemiology and Preventive Medicine, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima, Japan.
¹³ Department of Public Health, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan.
¹⁴ Department of Epidemiology for Community Health and Medicine, Kyoto Prefectural University of Medicine, Kyoto, Japan.
¹⁵ Department of Endocrine and Breast Surgery, Kyoto Prefectural University of Medicine, Kyoto, Japan.
¹⁶ Laboratory of Public Health, Division of Nutritional Sciences, School of Food and Nutritional Sciences, University of Shizuoka, Shizuoka, Japan.
¹⁷ NCD Epidemiology Research Center, Shiga University of Medical Science, Otsu, Japan.
¹⁸ Department of Cancer Epidemiology, Nagoya University Graduate School of Medicine, Nagoya, Japan.

^# Contributed equally.

Abstract

The prospective cohort study in a large Japanese population suggested that metabolic phenotypes are important risk factors for total and some site-specific cancers in Japanese adults. Moreover, the risk of each site-specific cancer may differ according to metabolic phenotypes.

Publication types

Multicenter Study

MeSH terms

Adult
Aged
Cohort Studies
Female
Humans
Japan / epidemiology
Male
Middle Aged
Neoplasms* / epidemiology
Neoplasms* / genetics
Neoplasms* / metabolism
Phenotype*
Prospective Studies
Risk Factors