There are no standard guidelines on the management of Conidiobolus infections, and many antifungals have been used, either alone or in combination. Relapses are common even after successful management. Although localized, they can result in severe facial disfigurement and may rarely cause disseminated entomophthoromycosis, which can have fatal complications. We present a case of biopsy-proven conidiobolomycosis in a young immunocompetent male patient with progressive unilateral rhinofacial swelling who was successfully treated with itraconazole monotherapy and showed no relapse after 1 year of therapy.