Global pattern of persistent human papillomavirus infection in female genital tract: An update system review and meta-analysis

Ming Zhao; Peipei Kang; Liling Zhu; Dan Zhou; Meimei Cui; Min Zhang; Jingjing Jia; Limei Luo

doi:10.1016/j.isci.2024.110991

Global pattern of persistent human papillomavirus infection in female genital tract: An update system review and meta-analysis

iScience. 2024 Sep 19;27(10):110991. doi: 10.1016/j.isci.2024.110991. eCollection 2024 Oct 18.

Authors

Ming Zhao^{1

2}, Peipei Kang³, Liling Zhu², Dan Zhou^{1

2}, Meimei Cui^{1

4}, Min Zhang^{1

2}, Jingjing Jia^{1

5}, Limei Luo^{1

6

6}

Affiliations

¹ Maternal and Child Health Development Research Center, Shandong Provincial Maternal and Child Health Care Hospital Affiliated to Qingdao University, Jinan, China.
² School of Public Health, Jiamusi University, Jiamusi, China.
³ Shandong Mental Health Center, Shandong University, Jinan, China.
⁴ School of Basic Medical, Weifang Medical College, Weifang, China.
⁵ School of Basic Medical, Jiamusi University, Jiamusi, China.
⁶ National Office for Maternal and Child Health Surveillance of China, National Center for Birth Defect Surveillance of China, Department of Pediatrics, West China Second University Hospital, Sichuan University, Chengdu, China.

Abstract

We analyzed the type-specific persistent infection of high-risk human papillomavirus (HR-HPV) across different continents, aiming to offer valuable insights into the implementation and development of HPV vaccines. There were 129 studies included 656,555 participants. The weighted mean time for any persistent HPV infection was 13.29 months. The single and multiple HPV infection were persistent for median of 12.27 and 18.99 months, respectively. HPV35 is the common genotype of persistent infection in Asia and Africa, as well as HPV53 in Europe. Individuals (>50 years old) were to be more prone to persistent infection. Our study revealed approximately 50% of persistent HPV infection resolved after two years. A 24-month interval for HPV testing is proposed as a way to identify persistent HPV infection. In addition, to develop region-specific guidelines for HPV vaccines can be utilized as references for the diagnosis and treatment of cervical cancer.

Keywords: Virology.