A Case of Syphilis With Ocular Involvement: Persistent Negative Serology in a Patient With Multiple Sclerosis

Open Forum Infect Dis. 2024 Oct 29;11(10):ofae563. doi: 10.1093/ofid/ofae563. eCollection 2024 Oct.

Abstract

Diagnostic algorithms for syphilis are based on serology. However, with the advent of immunosuppressive therapies, these algorithms may fail. We report a case of an individual with multiple sclerosis on treatment with ofatumumab and secondary syphilis with visual and auditory systems involvement and persistent negative treponemal and nontreponemal tests.

Keywords: multiple sclerosis; negative syphilis serology; ocular syphilis; ofatumumab; otosyphilis.