Diagnostic algorithms for syphilis are based on serology. However, with the advent of immunosuppressive therapies, these algorithms may fail. We report a case of an individual with multiple sclerosis on treatment with ofatumumab and secondary syphilis with visual and auditory systems involvement and persistent negative treponemal and nontreponemal tests.
Keywords: multiple sclerosis; negative syphilis serology; ocular syphilis; ofatumumab; otosyphilis.
© The Author(s) 2024. Published by Oxford University Press on behalf of Infectious Diseases Society of America.