Interrupted Michael Reaction: Sulfophosphinoylation of α,β-Unsaturated Ketones Catalyzed by Phosphine

J Org Chem. 2024 Oct 30. doi: 10.1021/acs.joc.4c01860. Online ahead of print.

Abstract

An efficient method for phosphine-catalyzed sulfophosphinoylation of α,β-unsaturated ketones for synthesis allylic organophosphorus compounds has been reported, in which α,β-unsaturated compounds acting as zwitterions react with electrophiles and nucleophiles to form a C-P bond and a C-O bond and obtain allylic organophosphorus with high regio- and stereoselectivity in moderate to excellent yields.