Objective: To investigate the clinical characteristics and treatment of patients with CD4+CD8- T-cell large granular lymphocytic leukemia (T-LGLL).
Methods: The clinical manifestations, diagnosis and treatment of 1 case of CD4+CD8- T-LGLL patient were reported, and relevant literatures were reviewed.
Results: The patient was a 70-year-old woman with slow clinical progress, mainly manifested by thrombocytopenia and myelodysplasia. The blood smear was mainly composed of large granular lymphocytes. Immunotyping and T-cell receptor gene rearrangement analysis showed that it was in line with T-LGLL. Partial remission(PR) was achieved through the treatment of cyclophosphamide(50 mg/d) combined with prednisone(gradually reduced and stopped later).
Conclusion: CD4+CD8- T-LGLL is very rare in clinical practice, and its clinical manifestations are different from those of CD4-CD8+ T-LGLL.
题目: CD4+CD8- T细胞大颗粒淋巴细胞白血病的临床分析.
目的: 探讨CD4+CD8- T细胞大颗粒淋巴细胞白血病（T-LGLL）患者的临床特征及诊疗方案。.
方法: 报告1例CD4+CD8- T-LGLL患者的临床表现、诊断及治疗情况，并结合文献进行回顾性分析。.
结果: 患者为老年女性（70岁），临床进展缓慢，以血小板减少为主要表现，骨髓增生较低下，血涂片以大颗粒淋巴细胞为主，免疫分型及T细胞克隆重排符合T-LGLL，应用环磷酰胺50 mg／d联合泼尼松（后逐渐减停）治疗，达到部分缓解（PR）。.
结论: CD4+CD8-T细胞大颗粒淋巴细胞白血病临床上极为罕见，与CD4-CD8+ T-LGLL临床表现存在差异。.
Keywords: CD4+CD8- T-cell large granular lymphocytic leukemia; clinical manifestations; treatment.