Update on the structure and function of Candida albicans drug efflux protein, Cdr1

Fungal Genet Biol. 2024 Dec:175:103938. doi: 10.1016/j.fgb.2024.103938. Epub 2024 Oct 30.

Abstract

Candida albicans is an important human pathogenic yeast, that can become resistant to commonly used antifungal agents, such as azoles. One mechanism of drug resistance is efflux via ATP binding cassette transporters, such as Cdr1. Several studies have investigated the structural organization, binding mechanisms, function and regulation of Cdr1. This review summarizes the findings on the structure and function of Cdr1 and highlights important aspects to consider in future research relating to multidrug ABC transporters.

Keywords: ATP binding cassette transporters; Candida albicans; Drug resistance.

Publication types

  • Review

MeSH terms

  • ATP-Binding Cassette Transporters / chemistry
  • ATP-Binding Cassette Transporters / genetics
  • ATP-Binding Cassette Transporters / metabolism
  • Antifungal Agents* / pharmacology
  • Azoles / pharmacology
  • Candida albicans* / drug effects
  • Candida albicans* / genetics
  • Candida albicans* / metabolism
  • Drug Resistance, Fungal / genetics
  • Fungal Proteins* / chemistry
  • Fungal Proteins* / genetics
  • Fungal Proteins* / metabolism
  • Humans
  • Membrane Transport Proteins* / chemistry
  • Membrane Transport Proteins* / genetics
  • Membrane Transport Proteins* / metabolism

Substances

  • Antifungal Agents
  • ATP-Binding Cassette Transporters
  • Azoles
  • CDR1 protein, Candida albicans
  • Fungal Proteins
  • Membrane Transport Proteins