Surface modification of cellulose nanocrystals for biomedical and personal hygiene applications

The increasing demand for sustainable and effective materials in biomedical and personal hygiene applications has driven the exploration of cellulose nanocrystals (CNCs) derived from biomass. These nanomaterials are highly valued for their exceptional mechanical properties, biocompatibility, and renewable nature. Researchers are exploring CNCs for advancing medical and hygiene products, but surface modification is often needed to maximize their benefits. Techniques such as chemical functionalization, physical coating, and hybridization can significantly enhance CNCs dispersibility, stability, and interaction with biological systems. This versatility makes CNCs suitable for a variety of applications, including drug delivery systems, wound dressings, and personal hygiene products. Despite their advantages, maintaining the inherent properties of CNCs while integrating new functionalities through modification poses a challenge. Understanding the impact of various modification techniques on CNC performance is crucial for optimizing their effectiveness. This review aimed to consolidate current knowledge on the surface modification of biomass-derived CNCs, offering insights into different methods and their implications for biomedical and personal hygiene applications. By highlighting advancements, challenges, and prospects, it served as a crucial resource for advancing the development and application of CNCs in these critical fields.