Prevalence and risk factors for seizures in adult COVID-19 patients: A meta-analysis

Seizures may be one of the neurological consequences of COVID-19. The present study aims to review the prevalence of seizures in COVID-19 patients considering sex and geographical origin. A review protocol was submitted to the PROSPERO database (CRD42021281467). PRISMA statement was used to report the meta-analysis. The authors selected studies for the meta-analysis by searching the principal databases. Studies were eligible if they reported seizures in COVID-19 patients, regardless of study design. Data were analyzed by proportion meta-analysis with a 95 % confidence interval (95 % CI). Cochran's Q and Higgins' I² were used to measure heterogeneity. R software was used for meta-analysis. Subgroup analyses were carried out for sex, geographical origin of the subjects, and illness severity. A checklist for prevalence studies was used to assess the risk of bias in the included studies. A total of 32 studies (n = 251,997 analyzed patients) were included in this meta-analysis. A prevalence of 1.03 % (95 % CI 0.73 to 1.37, I² = 93 %, p < 0.001) was found. No statistically significant differences were found in the analysis by geographical subgroups. Men were found to be less likely to had COVID-19 seizures (OR = 0.75, 95 % CI 0.21-2.74), while mildly ill patients were found to be more likely to had COVID-19-induced seizures (OR = 2.08, 95 % CI 0.86-5.06). Our results show a slight prevalence of seizures in COVID-19 patients. In addition, we found that the groups analyzed had differences in the odds of having COVID-19-induced seizures.