Standardizing MRI orientation improves reliability of entorhinal and transentorhinal cortical volume measurement

Yi-En Quek; Yi Leng Fung; Simon J Vogrin; Pierrick Bourgeat; Sara Vogrin; Jurgen Fripp; Steven J Collins; Stephen C Bowden; Alzheimer's Disease Neuroimaging Initiative

doi:10.1016/j.pscychresns.2023.111735

Standardizing MRI orientation improves reliability of entorhinal and transentorhinal cortical volume measurement

Psychiatry Res Neuroimaging. 2023 Oct 18:336:111735. doi: 10.1016/j.pscychresns.2023.111735. Online ahead of print.

Authors

Yi-En Quek¹, Yi Leng Fung², Simon J Vogrin³, Pierrick Bourgeat⁴, Sara Vogrin⁵, Jurgen Fripp⁴, Steven J Collins⁶, Stephen C Bowden⁷; Alzheimer's Disease Neuroimaging Initiative

Affiliations

¹ Melbourne School of Psychological Sciences, The University of Melbourne, Parkville, Victoria, Australia. Electronic address: [email protected].
² Melbourne School of Psychological Sciences, The University of Melbourne, Parkville, Victoria, Australia.
³ Department of Clinical Neurosciences, St Vincent's Hospital Melbourne, Fitzroy, Victoria, Australia.
⁴ The Australian e-Health Research Centre, CSIRO Health and Biosecurity, Herston, Queensland, Australia.
⁵ Department of Medicine, St Vincent's Hospital Melbourne, The University of Melbourne, Fitzroy, Victoria, Australia.
⁶ Department of Clinical Neurosciences, St Vincent's Hospital Melbourne, Fitzroy, Victoria, Australia; Department of Medicine, The Royal Melbourne Hospital, The University of Melbourne, Parkville, Victoria, Australia.
⁷ Melbourne School of Psychological Sciences, The University of Melbourne, Parkville, Victoria, Australia; Department of Clinical Neurosciences, St Vincent's Hospital Melbourne, Fitzroy, Victoria, Australia.

PMID: 39492186
DOI: 10.1016/j.pscychresns.2023.111735

Abstract

The current study compared the reliability of manual collateral sulcus depth and entorhinal and transentorhinal cortical volume measurements between native oriented MRI scans versus MRI scans realigned to the hippocampal long axis. Data included 10 participants with two serial 3.0T MRI scans from the Alzheimer's Disease Neuroimaging Initiative. Both collateral sulcus depth and entorhinal and transentorhinal cortical volume measurement reliability improved from the native to the hippocampal oriented scans. Standardizing scan orientation is important to optimize reliability of MRI-derived manual measurements of the entorhinal and transentorhinal cortices. In quantitative MRI studies, aligning scans to a common, normalized orientation is recommended.

Keywords: Entorhinal cortex; Magnetic resonance imaging; Transentorhinal cortex.