Exploration of One-Pot, Tandem Sulfamoylation and aza-Michael Cyclization Reactions for the Syntheses of Oxathiazinane Dioxide Heterocycles

J Org Chem. 2024 Nov 15;89(22):16774-16778. doi: 10.1021/acs.joc.4c02086. Epub 2024 Nov 4.

Abstract

We show the first examples of one-pot tandem sulfamoylation/aza-Michael reactions for the preparation of oxathiazinane dioxide heterocycles from linear alkenyl alcohol precursors. Our optimized protocols are tolerant of a variety of functional groups and provide products that are amenable for further transformations. The reactions scale well, and no special precautions are required to exclude air or ambient moisture.