Targeting uridine diphosphate glucuronosyltransferase 1A1 in liver disease: Current research and future directions

Seok-Chan Park; Yu Ji Kim; Jong-Won Kim

doi:10.3748/wjg.v30.i39.4305

Targeting uridine diphosphate glucuronosyltransferase 1A1 in liver disease: Current research and future directions

World J Gastroenterol. 2024 Oct 21;30(39):4305-4307. doi: 10.3748/wjg.v30.i39.4305.

Authors

Seok-Chan Park¹, Yu Ji Kim², Jong-Won Kim³

Affiliations

¹ Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY 10029, United States.
² Division of Endocrinology and Metabolism, Department of Internal Medicine, Medical School, Jeonbuk National University, Research Institute of Clinical Medicine of Jeonbuk National University-Biomedical Research Institute of Jeonbuk National University Hospital, Jeonju 54907, South Korea.
³ Center for Pharmacogenetics and Department of Pharmaceutical Sciences, University of Pittsburgh, Pittsburgh, PA 15216, United States. [email protected].

Abstract

The current letter to the editor pertains to the manuscript entitled 'Uridine diphosphate glucuronosyltransferase 1A1 prevents the progression of liver injury'. Increased levels of uridine diphosphate glucuronosyltransferase 1A1 during liver injury could mitigate damage by reducing endoplasmic reticulum stress, oxidative stress, and dysregulated lipid metabolism, impeding hepatocyte apoptosis and necroptosis.

Keywords: Endoplasmic reticulum stress; Lipid metabolism disorders; Liver injury; Oxidative stress; Uridine diphosphate glucuronosyltransferase 1A1.

Publication types

Letter

MeSH terms

Animals
Apoptosis*
Endoplasmic Reticulum Stress*
Glucuronosyltransferase* / genetics
Glucuronosyltransferase* / metabolism
Hepatocytes / enzymology
Hepatocytes / metabolism
Humans
Lipid Metabolism
Liver Diseases / enzymology
Liver Diseases / metabolism
Liver Diseases / pathology
Liver* / enzymology
Liver* / pathology
Molecular Targeted Therapy / methods
Oxidative Stress*

Substances

Glucuronosyltransferase
UGT1A1 enzyme