A chiral ionic organic single-crystal (CIOC) was prepared for the first time through ionic self-assembly using bipyridium chiral ionic liquid (CIL) and 4,4'-biphenyldisulfonic acid (BDA). The CIOC can be ultrasonically exfoliated to produce two-dimensional nanosheets (2D-NSs). The 2D-NSs presented enhanced enantioseparation compared to the CIOC and CIL when used as gas chromatography stationary phase, which may be due to the exfoliated 2D-NSs exhibiting greater exposure of functional groups. Additionally, better resolution of other organic compounds such as positional isomers, n-alkanes and n-alkanols, Grob mixture, phenols and anilines was obtained in 2D-NSs than CIOC and CIL. This work not only provides a reference for the preparation of chiral ionic organic single-crystals and two-dimensional nanosheets for chiral separation, but also stimulates the preparation of such new ionic organic single-crystals via self-assembly for other potential applications.
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