Efficacy and Safety of Dolutegravir Plus Emtricitabine vs Combined Antiretroviral Therapy for the Maintenance of HIV Suppression: Results Through Week 144 of the SIMPL'HIV Trial

Open Forum Infect Dis. 2024 Oct 16;11(11):ofae618. doi: 10.1093/ofid/ofae618. eCollection 2024 Nov.

Abstract

The SIMPL'HIV study investigated whether switching to dolutegravir (DTG) + emtricitabine (FTC) was noninferior to continuing combined antiretroviral therapy for maintaining HIV-1 suppression at 144 weeks. The study demonstrated that viral suppression, CD4 gains, adverse events, quality of life, and patient satisfaction were comparable between groups, confirming DTG + FTC's safety and efficacy for long-term management of HIV-1 infection.

Keywords: HIV-1 dual therapy; dolutegravir + emtricitabine; maintenance treatment; patient satisfaction; quality of life.

Publication types

  • Clinical Trial