The SIMPL'HIV study investigated whether switching to dolutegravir (DTG) + emtricitabine (FTC) was noninferior to continuing combined antiretroviral therapy for maintaining HIV-1 suppression at 144 weeks. The study demonstrated that viral suppression, CD4 gains, adverse events, quality of life, and patient satisfaction were comparable between groups, confirming DTG + FTC's safety and efficacy for long-term management of HIV-1 infection.
Keywords: HIV-1 dual therapy; dolutegravir + emtricitabine; maintenance treatment; patient satisfaction; quality of life.
© The Author(s) 2024. Published by Oxford University Press on behalf of Infectious Diseases Society of America.