A road to rupture: New insights into the loss of micronuclear membrane integrity

Shane M Harding

doi:10.1016/j.molcel.2024.10.018

A road to rupture: New insights into the loss of micronuclear membrane integrity

Mol Cell. 2024 Nov 7;84(21):4056-4058. doi: 10.1016/j.molcel.2024.10.018.

Author

Shane M Harding¹

Affiliation

¹ Princess Margaret Cancer Center, University Health Network, Toronto, ON, Canada; Departments of Medical Biophysics, Immunology and Radiation Oncology, University of Toronto, Toronto, ON, Canada. Electronic address: [email protected].

PMID: 39515293
DOI: 10.1016/j.molcel.2024.10.018

Abstract

In two recent studies in Science, Martin et al. and Di Bona et al.¹^,² showed that mitochondrial-derived reactive oxygen species (ROS) drive mechanisms responsible for micronuclei membrane rupture, with important implications for cancer.

MeSH terms

Animals
Cell Membrane / metabolism
Humans
Micronuclei, Chromosome-Defective
Mitochondria* / genetics
Mitochondria* / metabolism
Mitochondria* / pathology
Neoplasms / genetics
Neoplasms / metabolism
Neoplasms / pathology
Reactive Oxygen Species* / metabolism

Substances

Reactive Oxygen Species