Lumbar Transforaminal Injections of Nusinersen in Spinal Muscular Atrophy Patients

Eric J Monroe

doi:10.1016/j.nic.2024.08.003

Lumbar Transforaminal Injections of Nusinersen in Spinal Muscular Atrophy Patients

Neuroimaging Clin N Am. 2025 Feb;35(1):77-83. doi: 10.1016/j.nic.2024.08.003. Epub 2024 Sep 5.

Author

Eric J Monroe¹

Affiliation

¹ Department of Radiology, Section of Vascular and Interventional Radiology, University of Wisconsin, 600 Highland Avenue, Madison, WI 53792, USA. Electronic address: [email protected].

PMID: 39521528
DOI: 10.1016/j.nic.2024.08.003

Abstract

Following a review of spinal muscular atrophy pathogenesis and current therapeutics, a comprehensive review of transforaminal lumbar injections is provided. Patient preparation, special considerations, procedural technique, complications, and alternative approaches are discussed.

Keywords: Computed tomography; Fluoroscopy; Interventional; Intrathecal; Lumbar puncture; Nusinersen; Spinal muscular atrophy; Transforaminal.

Publication types

Review

MeSH terms

Humans
Injections, Epidural / methods
Injections, Spinal / methods
Lumbar Vertebrae / diagnostic imaging
Muscular Atrophy, Spinal* / diagnostic imaging
Muscular Atrophy, Spinal* / drug therapy
Oligonucleotides* / administration & dosage
Oligonucleotides* / therapeutic use

Substances

nusinersen
Oligonucleotides